直播时间：2025年7月8日（周二）20:00-21:30

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北京时间7月8日晚八点，iCANX Youth Talks第105期邀请到了上海交通大学溥渊未来技术学院长聘教轨副教授王敏强、上海交通大学医学院研究员叶萃、上海科技大学生物医学工程学院助理教授于游担任主讲，南方科技大学深港微电子学院助理教授林苑菁担任研讨嘉宾，北京大学集成电路学院教授张海霞担任主持人，期待你一起加入这场知识盛宴。

王敏强

上海交通大学

用于个性化医疗的可穿戴生物电子

【Abstract】

The continuous improvement in living standards and accelerated aging population have positioned personalized medicine to play a pivotal role in future healthcare, with the potential to fundamentally transform traditional reactive medicine. This creates significant opportunities for developing wearable devices designed for predictive analytics and therapeutic applications. In this presentation, I will introduce our research advances in wearable biosensors for non-invasive molecular profiling. These devices can autonomously collect biofluids (e.g., sweat) during physical activities and continuously monitor a wide range of analytes including metabolites, nutrients, hormones, and pharmaceuticals. We employ laser engraving and inkjet printing technologies to enable large-scale, cost-effective manufacturing of high-performance nanomaterial-based biosensors. Through multiple clinical trials focusing on precision nutrition, stress/mental health assessment, chronic disease management, and personalized drug therapy, we have systematically evaluated the clinical value of our wearable systems. These wearable technologies could unlock new possibilities for a broad spectrum of personalized monitoring, diagnostic, and therapeutic applications.

随着人民生活水平的提高及老龄化的加剧，个性化医疗在未来医疗中将扮演至关重要的角色，预计将彻底改变传统被动医疗。这为开发应用于预测分析和治疗的穿戴式设备提供了巨大机遇。本次报告将介绍我们在开发非侵入性分子分析穿戴式生物传感器方面的研究成果。此类设备能够自主获取人体活动过程中产生的体液（如汗液），并持续监测包括代谢物、营养物质、激素和药物在内的多种分析物。我们采用激光雕刻和喷墨打印技术，实现了高性能纳米材料生物传感器的大规模低成本制造。通过针对精准营养、压力/心理健康评估、慢性病管理和个性化用药等领域开展的多项人体试验，系统评估了穿戴系统的临床价值。这些可穿戴技术有望为广泛的个性化监测、诊断和治疗应用开辟新的大门。

【BIOGRAPHY】

Dr. Minqiang Wang is currently tenure-track associate professor in Shanghai Jiao Tong University at GIFT, before joining SJTU, he was a postdoctoral scholar at California Institute of Technology, under the supervision of Dr. Wei Gao. His research is interdisciplinary and focused on developing new types of versatile energy materials and bioelectronic wearable systems that could be used for fundamental and applied biomedical studies. His research interests include Nano-materials, Wearable devices, Biosensors, Bioelectronics, Analytical electrochemistry, Nanotechnology, Microfluidics, Personalized medicine, Electrocatalysis. Dr. Minqiang Wang has published 21 scientific papers in journals such as “Nature Materials, Nature Biomedical Engineering, Nature Nanotechnology, etc.” as the first author or corresponding author. A total of citations is over 6, 400, and h-index is 39. He won the first-tier prize of Baxter Young Investigator (one out of six around the world), and participated in several grants, including the US NIH, NSF, ACS projects with a total amount of more than 3 million US dollars.

王敏强博士现任上海交通大学溥渊未来技术学院长聘教轨副教授。在加入上海交大前，他曾任加州理工学院博士后研究员，师从高伟教授。他的研究具有鲜明的学科交叉特色，主要致力于开发新型多功能能源材料与生物电子可穿戴系统，以推动基础生物医学研究和临床应用。研究领域涵盖纳米材料、可穿戴设备、生物传感器、生物电子学、分析电化学、纳米技术、微流控、个性化医疗及电催化等方向。王敏强博士以第一作者或通讯作者身份在Nature Materials， Nature Biomedical Engineering， Nature Nanotechnology等顶级期刊发表论文21篇，总被引次数逾6400次，H指数达39。他曾荣获"Baxter Young Investigator"最高级别奖项（全球每年仅6人获此殊荣），并参与美国国立卫生研究院（NIH）、国家科学基金会（NSF）和美国化学学会（ACS）等多个科研项目，累计获得科研经费超过300万美元。

叶萃

上海交通大学

可穿戴超灵敏电子传感及主动女性健康管理

【ABSTRACT】

With the deepening of national digital transformation and the “Healthy China” initiative, non-invasive wearable sensing technologies are emerging as a research frontier in the field of health management. Ultra-sensitive wearable sweat analysis platforms that integrate flexible electronics, microfluidics, and electrochemical analysis enable real-time and continuous monitoring of physiological and metabolic signals, offering new opportunities for early disease screening, personalized diagnosis, and proactive health management. Sweat, as a biofluid rich in diverse biomarkers, reflects key physiological parameters such as metabolic status and hormone levels. Its non-invasive and continuously accessible nature makes it especially valuable for the digital and intelligent management of women’s health. For instance, fluctuations in female hormone levels are closely associated with fertility, menstrual disorders, and menopause, and are critical for monitoring, intervention, and therapeutic evaluation in conditions such as infertility, polycystic ovary syndrome (PCOS), and menopausal transition. This report focuses on the precise detection of ultra-low concentration biomarkers in sweat, introducing the development of high-performance sweat sensing platforms from the perspectives of molecular recognition mechanisms, microfluidic chip design, and wearable system integration. It systematically reviews recent advances in sensor sensitivity, selectivity, and stability, and highlights strategies to address challenges such as signal interference, miniaturization, and long-term wearability. Furthermore, it explores the promising applications of these platforms in the digital and intelligent management of women’s health, particularly in scenarios requiring continuous, real-time hormone monitoring for reproductive health tracking, menstrual cycle analysis, early diagnosis of endocrine disorders, and personalized intervention.

随着国家数字化转型及“健康中国”战略的深入推进，智能无创可穿戴传感技术成为健康管理领域的研究热点。其中，可穿戴超灵敏汗液分析技术通过集成柔性电子传感、微流控技术和电化学分析等前沿手段，能够实时监测人体生理和代谢信息，对疾病早期诊断和主动健康管理具有重要作用。汗液作为一种富含生物标志物的体液，能够反映人体代谢状态、女性荷尔蒙水平等生理指标，尤其在数智化女性健康管理中具有独特应用价值。例如，女性荷尔蒙水平变化与生育能力、痛经、绝经等健康问题密切相关，在不孕症、多囊卵巢综合征、绝经管理等女性健康相关的疾病监测、预防及治疗中至关重要。本报告将围绕汗液中超低浓度生物标志物的分析，从分子传感机理、微流控芯片设计及可穿戴系统集成等角度，介绍可穿戴超灵敏汗液传感技术的开发，着重探讨其在数智化女性健康管理中的应用。

【BIOGRAPHY】

Dr. Cui Ye completed her postdoctoral research at the California Institute of Technology (Caltech) in early 2025 and joined Shanghai Jiao Tong University as a Principal Investigator (doctoral supervisor, and discipline leader). Her primary research focuses on flexible electronic sensing, with an emphasis on wearable biosensors, non-invasive sweat monitoring, electrochemical analysis, microfluidics, and personalized digital health management. To date, she has published over 50 papers with a total of 3,500 citations and an h index of 30. As the first or corresponding author, she has published 24 research articles in prestigious journals such as Nature Nanotechnology, Nature Materials, and Chemical Society Reviews, with her work highlighted by Nature, among others. She has led two national and provincial-level research projects and holds four authorized Chinese patents and one international patent (licensed and secured funding support). She currently serves as a Scientific Advisor at Persperity Health, and a Youth Editorial Board Member for The Innovation and Advanced Powder Materials and as an independent reviewer for Nature Communications.

叶萃博士，于2025年初结束美国加州理工学院博士后研究工作，以研究员（博导、独立PI及学科带头人）岗入职上海交通大学医学院。主要从事柔性电子传感研究，聚焦于穿戴式生物传感、无创汗液监测、电化学分析、微流控、个性化数字健康管理等领域。迄今为止，在相关领域期刊发表SCI论文50余篇，学术总被引3500次，h指数30。以第一/通讯作者共计发表学术论文24篇，包括Nature Nanotechnology，Nature Materials，Chemical Society Reviews等，研究成果被Nature等高亮报道。主持国家及省部级别项目2项。授权中国发明专利4项，国际专利1项。基于可穿戴关键技术成立初创公司Persperity Health，并获融资支持。担任The Innovation，Advanced Powder Materials期刊青年编委及Nature Communications独立审稿人。

于游

上海科技大学

柔性生物电子：多模式传感界面的发展

【ABSTRACT】

Integration of flexible bioelectronics and biomarker monitoring is a rapidly growing research area driven by its promising potential to assist personal healthcare and sustainable environmental managements. Flexible technology introduces novel devices by merging materials science, device manufacture, and medical application. Here, we have developed a biofuel-powered soft electronic skin for multiplexed wireless perspiration analysis, that can selectively measure a wide spectrum of sweat analytes including glucose, uric acid, and urea, to provide insightful individual`s health information. On the other hand, flexible robotic electronics that mimic and surpass human sensing capabilities is critical to support the further robotic applications. Till now, integrating ultrasensitive physical and chemical sensors for in situ analytic sensing is rather extremely challenging and underdeveloped. We have developed fully-printed soft human-machine interface for robotic physicochemical sensing, which can perform proximity sensing, tactile and temperature perceptual mapping, alongside real-time hydrogel-assisted electrochemical sampling and analysis of chemical threat and biohazards (e.g. SARS-CoV-2 virus)

柔性生物电子在生物医学工程领域有着广阔的发展前景，包括个人健康监测，疾病早期诊断治疗以及医疗机器人等领域。柔性电子集合了材料科学，工程设备制造，医学应用等多个方面，并体现出独特的应用前景。研究工作主要聚焦于柔性生物电子在可穿戴健康监测，生物质自供能装置，及柔性人机交互界面等三个方面的研究。首次提出了一种全生物质供能的可穿戴多模式传感装置，这种装置可以对于人体汗液中的代谢产物进行实时分析，反应人体代谢状态，并且此装置完全由汗液本身进行供能并通过蓝牙通讯无线传递数据。与此同时，基于喷墨打印技术制作了一种多模式传感电子皮肤，将电子皮肤分别置于机械端与人体控制端，在人工智能的帮助下通过获取不同手势的肌电信号实现高效的人机交互。这种机械手上的电子皮肤不仅可以给机械手提供触觉信息，还可以提供环境的特定有害物质的化学信息，如爆炸物，神经毒气以及病毒等。

【BIOGRAPHY】

Dr. You Yu is an Assistant Professor in the School of Biomedical Engineering at ShanghaiTech University. He recieved his Ph.D. degree at 2017 in Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. After that, he worked as a postdoctoral research associate in the department of Medical Engineering at California Institute of Technology. He is awarded by Shanghai Pujiang Talent Program, Shanghai Academic Research Leader, MINE Young Scientist Award by Microsystems & Nanoengineering, Young Scientist Award by China Association for Science and Technology (CAST). He has published over 20 peer reviewed journal articles with over 1800 citations, including Sci. Robotic. (2), Adv. Mater., Sci. Adv., IEEE JSSC. His research is concentrated on the development and application of soft bioelectronics and medical robotics.

于游博士，上海科技大学生物医学工程学院助理教授、研究员、博士生导师。于中国科学院长春应用化学研究所获得分析化学博士学位，随后在加州理工学院医学工程系进行博士后研究。于游博士入选上海市浦江人才、上海市领军人才、上海科技青年35人引领计划、浦东新区明珠菁英人才，并获得微系统与纳米工程青年科学家，中国新锐科技人物等奖项 。研究兴趣集中于柔性生物电子、可穿戴传感器、人机交互、医疗机器人等领域。目前已在相关领域期刊发表高水平论文20余篇，H因子19，近五年引用超2500次，包括 Sci. Robotic., Nat. Electron., Adv. Mater., Sci.Adv., IEEE JSSC 等，受邀撰写国际出版社著作章节3章。主持上海市市科委项目，国家自然科学基金项目以及腾讯Robotics X犀牛鸟研究计划等。

【主持人】

张海霞

北京大学

【研讨嘉宾】

林苑菁

南方科技大学