直播时间：2025年11月25日（周二）20:00-21:30

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北京时间11月25日晚八点，iCANX Youth Talks第125期邀请到了香港城市大学校长特聘助理教授刘佳琦，洛桑联邦理工学院助理教授张瑜伽担任主讲嘉宾，电子科技大学教授张晓升，上海科技大学助理教授于游研讨嘉宾，电子科技大学特聘研究员潘泰松担任主持人，期待你一起加入这场知识盛宴。

【嘉宾介绍】

刘佳琦

香港城市大学

生物集成材料器件与超声技术的融合

【Abstract】

Soft, bio-integrated materials and devices exhibit the ability to collect physiological signals and offer therapeutic functions, posing a substantial impact on our understanding of biology and paving the way for precision medicine. With the assistance of advanced ultrasound technology, the innovative integration holds immense promise for sensing, modulation and actuation in deep tissues and complex anatomical structures that are otherwise difficult to approach. In this talk, I will highlight our recent advances in bioresorbable, shape-adaptive materials structures that enable real-time monitoring of deep-tissue homeostasis using ultrasound instruments. Specifically, this bio-integrated device incorporates symmetrically distributed metal discs that generate strong contrast in ultrasound images embedded within a soft, pH-responsive hydrogel matrix, to allow ultrasound-based measurements of local pH variation. The envisioned clinical use is in early assessments of anastomotic leaks that can occur following gastrointestinal surgeries, where bioresorption after a recovery period bypasses the need for surgical extraction. I will conclude by discussing opportunities in leveraging functional soft materials and ultrasound to measure biosignals, provide targeted modulation and programmable actuation to decipher biological systems and improve healthcare.

柔性生物集成材料与器件能够采集生理信号并提供治疗功能，这对我们理解生命机制具有重要意义，并为精准医疗开辟了新途径。结合先进超声技术，这类集成器件为深部组织和复杂解剖结构中的传感、调控与驱动提供了全新思路。本报告将重点介绍我们在生物可吸收、形状自适应材料结构方面的最新进展，该技术利用超声实现了深部组织稳态的实时监测。具体而言，这种生物集成器件由对称分布的金属圆盘嵌入pH响应性水凝胶基质构成，通过金属结构在超声图像中产生的高对比度，实现了基于超声的局部pH变化测量。其临床应用旨在为术后泄漏提供精准、及时监测以便早期干预，器件在康复期后的生物可吸收特性避免了二次手术取出的需求。最后，我将展望功能柔性材料与超声技术相结合在生物信号检测、靶向调控和程序化驱动方面的应用前景。

【BIOGRAPHY】

Dr. Jiaqi Liu is a Presidential Assistant Professor in the Department of Mechanical Engineering at City University of Hong Kong. Before joining CityUHK in 2025, she was a postdoctoral scholar in the Querrey Simpson Institute for Bioelectronics at Northwestern University, working with Prof. John A. Rogers. She received her Ph.D. in Materials Science and Engineering from University of Pennsylvania under the supervision of Prof. Shu Yang in 2021. She obtained her B.S. in Materials Science from Fudan University in 2016. Her research focuses on leveraging functional soft materials, advanced manufacturing, ultrasound technology, and bioengineering approaches to advance multifunctional bio-integrated devices for measuring biological and biophysical signals, providing target modulation, and programming soft robotic actuators towards biomedical and healthcare applications. She has been selected as a Protostar by the weekly newsletter of Science magazine and has been awarded the Sidney J. Stein Prize and the Geoffrey Belton Graduate Fellowship by the University of Pennsylvania.

刘佳琦，香港城市大学机械工程系校长特聘助理教授，博士生导师。曾为美国西北大学Querrey Simpson 生物电子研究所博士后，导师美国四院院士John A. Rogers教授。2021年博士毕业于美国宾夕法尼亚大学材料科学与工程系，师从Shu Yang教授，2016年本科毕业于复旦大学材料系。近五年来以第一作者身份在Science、PNAS等顶级期刊发表多篇重要论文，研究致力于围绕功能材料、先进制造、超声技术和生物工程等方法，通过传感、调控和驱动开发生物医用器件，聚焦智慧医疗。她曾当选Science期刊“明日之星”，并获宾夕法尼亚大学 Sidney J. Stein 奖项和Geoffrey Belton研究生奖学金。

张瑜伽

洛桑联邦理工学院

用于生物接口的微尺度模块化多功能液滴离电子系统

【ABSTRACT】

Hydrogel iontronic devices can emulate biological functions and communicate with living matter. However, the fabrication of miniature, soft iontronic devices according to modular designs has not been achieved. In the talk, I will discuss the use of surfactant-supported assembly of freestanding microscale hydrogel droplets, termed dropletronics, to construct various ionic power sources, iontronic modules, circuits, and biointerfaces. The tiny, versatile dropletronic devices enable a variety of biomedical applications, including modulation of humanbrain organoids, defibrillation and pacing of mouse hearts, and recording electrophysiological signals from sheets of human cardiomyocytes. I will also introduce some ongoing projects in my group, Laboratory for Bio-Iontronics (BION) at EPFL, and conclude by summarizing the major challenges in the field and future directions.

基于水凝胶的离子电子器件能够模拟生物组织的诸多特点和功能，从而用于智能生物接口。然而，可模块化设计制造的、微型、柔性、离子电子器件这一重大需求尚未被解决。本次报告中，我将探讨利用表面活性剂辅助自组装的水凝胶液滴系统（称为液滴离电子系统）来构建各种离子电源、离子电子模块、电路和生物接口器件。这些微米尺寸、模块化的、多功能液滴离电子器件可应用于多种生物医学领域，包括调控人源类脑器官神经活动、小鼠心脏除颤和起搏、以及记录人源心肌细胞的多种电生理信号等。此外，我还会简要介绍我课题组（BION）的研究方向，并总结离子电子领域面临的主要挑战和未来的多种应用领域。

【BIOGRAPHY】

Dr. Yujia Zhang is a Tenure Track Assistant Professor of Electrical and Micro Engineering at the School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL). He has led the Laboratory for Bio-Iontronics (BION) since 2025. A major interest of his laboratory is the development of iontronic biointerfaces for medicine and hybrid intelligent systems. Recently, he has pioneered dropletronics, in which networks of microscale soft droplets function as versatile bioiontronic/bioelectronic devices. Prior to his appointment, he obtained his B.Sc. in Electronics Engineering from the University of Science and Technology of China (USTC) in 2016. Later, he completed his PhD in biomedical engineering and MEMS/NEMS technology at the Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences (CAS), followed by one year as a visiting PhD student at Stony Brook University in the US. In 2021, Yujia joined the Bayley group at the University of Oxford, UK, and in 2023, he became an independent early-career research fellow hosted in the Department of Chemistry at the University of Oxford. Yujia has published over 40 peer-reviewed journal articles and conference proceedings, including Nature (2023), Science (2024), etc. Yujia also serves as a reviewer and guest editor for several scientific journals, including Nature Materials, Nature Electronics, Science Advances, and Iontronics. Meanwhile, he is an active member of the Royal Society of Chemistry and the International Society of Bionic Engineering. Yujia is the recipient of many prestigious national and international awards, including the Special Prize of President Scholarship for Postgraduate Students, CAS (2020), the Early-career Scientist Representative by the UK Parliamentary and Scientific Committee (2023), and the Young Scientist Award by the iCANX Global Summit (2025).

张瑜伽博士，洛桑联邦理工学院（EPFL，瑞士）助理教授，博士生导师，生物离子电子学实验室（BION）学术带头人。2016年本科毕业于中国科学技术大学，2020年博士毕业于中国科学院上海微系统与信息技术研究所（SIMIT），并于美国纽约石溪大学进行博士访问，2021年在英国牛津大学开展博士后工作，导师为Hagan Bayley教授，并于2023年成为牛津大学化学系独立青年研究员。近五年来以第一作者身份在Nature、Science等顶级期刊发表40余篇重要论文，研究致力于开发用于生物医学和智能系统的生物离子电子器件。他曾荣获多项国内外知名奖项，包括中国科学院院长研究生奖学金特别奖（2020）、英国议会与科学委员会青年科学家代表奖（2023）、以及iCANX全球峰会青年科学家奖（2025）。

【主持人】

潘泰松

电子科技大学

【研讨嘉宾】

张晓升

电子科技大学

于游

上海科技大学