直播时间：2025年11月11日（周二）20:00-21:30

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北京时间11月11日晚八点，iCANX Youth Talks第123期邀请到了芝加哥大学博士黎鹏举、约翰霍普金斯大学助理教授杨笑担任主讲嘉宾，新加坡国立大学博士肖潇、瑞士苏黎世联邦理工学院博士后研究员杨伟峰担任研讨嘉宾，上海科技大学教授熊泽担任主持人，期待你一起加入这场知识盛宴。

【嘉宾介绍】

黎鹏举

芝加哥大学

光电治疗平台：从亚细胞到器官的无线生物调控

【Abstract】

This talk presents a materials-based, non-genetic approach to wireless and minimally invasive optoelectronic modulation spanning subcellular to organ scales. It integrates two complementary studies on semiconductor-enabled interfaces that harness photoelectrochemical processes for both electrical and biochemical control of biological systems. The first demonstrates tunable, spatiotemporal photostimulation using monolithic silicon-based photoelectrochemical devices capable of leadless, multisite cardiac pacing—from cultured cardiomyocytes and isolated rodent hearts to in vivo optical resynchronization in a pig heart, enabled by a custom endoscopic delivery system. The second reveals how nanoporous silicon photocatalysts generate controlled hydrogen peroxide under physiological conditions, allowing modulation of intracellular stress granule dynamics and improving cellular resilience to oxidative stress. Applied to myocardial ischaemia–reperfusion models, this mild catalytic pretreatment reduces infarction and functional loss. These studies establish the foundation of photoelectroceuticals—semiconductor-based platforms that couple light-driven charge and catalytic processes to achieve precise, wireless modulation of biological function.

本报告介绍一种基于材料、无需基因改造的无线、微创光电调控策略，作用范围从亚细胞尺度延伸至整个器官。研究整合了两项互为补充的工作，探讨如何利用半导体驱动的光电化学过程，实现对生物系统的电学与生化双重调控。第一部分展示了基于单片硅的光电化学器件在可调空间与时间分辨的光刺激中的应用，可实现无导线、多位点的心脏起搏——从培养的心肌细胞、离体啮齿动物心脏，到首次在大型动物（猪）体内实现光学再同步起搏，配合定制的内窥式光学传递系统完成闭胸操作。第二部分揭示了纳米多孔硅光催化剂在生理条件下可控生成过氧化氢的机制，从而调节细胞内应激颗粒的动态行为，并增强细胞对氧化应激的耐受性。将该光电化学策略应用于心肌缺血再灌注模型时，温和的催化预处理可有效减轻心肌梗死与功能损伤。以上研究共同奠定了“光电治疗平台（photoelectroceuticals）”的基础——一种利用光驱动电荷与催化过程，实现对生物功能精确、无线调控的半导体平台。

【BIOGRAPHY】

Dr. Pengju Li received his Ph.D. in Molecular Engineering from the University of Chicago and his B.Eng. in Materials Science and Engineering from the National University of Singapore. He is a recipient of the MIT Technology Review Innovators Under 35 (TR35) Asia Pacific Award and the ACS Division of Inorganic Chemistry Young Investigator Award. His research pioneers the emerging field of photoelectroceuticals—integrating optoelectronic semiconductor materials with living systems to achieve wireless and minimally invasive modulation of deep tissues. Dr. Li’s studies span from fundamental investigations of photoelectrochemical processes within cells to translational demonstrations in preclinical small and large animal models, including the demonstration of non-invasive modulation in neuromuscular control of limb, tongue, diaphragm, and heart functions. These works present promising pathways toward treatments for paralysis, obstructive and central sleep apnea, and cardiac dysfunction. His work has been published in journals including Nature, Nature Materials, and Nature Nanotechnology.

黎鹏举博士于芝加哥大学普利兹克分子工程学院获得博士学位，并于新加坡国立大学获得材料科学与工程学士学位。他是麻省理工科技评论“35岁以下创新者”（TR35）亚太区获奖者，以及美国化学会无机化学分部青年科学家奖获得者。他的研究开创“photoelectroceuticals”这一新兴领域——将光电半导体材料与生物系统相融合，实现对深层组织的无线、微创调控。黎博士的研究从细胞内光电化学过程的基础机制出发，延伸至小动物和大型动物模型的转化研究，包括在肢体、舌头、膈肌和心脏等多种神经肌肉功能中的非侵入式调控示范。这些成果为瘫痪、阻塞性与中枢性睡眠呼吸暂停及心脏功能障碍等疾病的治疗提供了新的方向。这些研究成果发表在《Nature》《《Nature Materials》《Nature Nanotechnology》等国际学术期刊上。

杨笑

约翰霍普金斯大学

用于脑机接口的仿生电子学

【ABSTRACT】

Bioelectronic devices have been very important as fundamental research tools for probing and understanding the brain with high spatiotemporal resolution, and as therapeutic avenues for treating brain diseases, disorders, and injuries. We draw inspiration from biological systems and art forms to design and develop a series of bio-inspired and art-inspired bioelectronics for broad applications in brain-machine interfaces, regenerative medicine, and the study of human neural development and diseases. Our studies encompass neural probes for in vivo brain-machine interface, electronic scaffolds for brain repair, and platforms for detecting human genetic diseases and tracking human neural development using human brain organoids.

生物电子学器件作为基础研究工具，在高时空分辨率下探测和理解大脑方面具有重要作用，同时也为治疗脑部疾病和损伤提供了重要的治疗途径。我们从生物系统和艺术形式中汲取灵感，设计并开发了一系列仿生和艺术启发的生物电子学器件，广泛应用于脑机接口、再生医学以及人类神经发育与疾病研究。我们的研究涵盖了用于活体脑机接口的神经探针、用于大脑修复的神经电子支架，以及用于人类大脑类器官检测遗传疾病和追踪神经发育的平台。

【BIOGRAPHY】

Dr. Xiao Yang is an Assistant Professor in the Department of Biomedical Engineering at Johns Hopkins University since 2025 and is an affiliate member of the Translational Tissue Engineering Center and the Center for Microphysiological Systems. Previously, Dr. Yang was a Wu Tsai Neurosciences Institute Interdisciplinary Postdoctoral Scholar at Stanford University. She received her Ph.D. in Chemistry from Harvard University, and her B.S. in Chemistry at Peking University. Her lab works on developing bio-inspired and art-inspired bioelectronics for brain-machine interfaces and regenerative medicine. Xiao’s research has been published in journals including Nature Biotechnology, Nature Biomedical Engineering, Nature Materials, Nature Reviews Bioengineering, and others. She has received the Maryland Stem Cell Research Fund Launch Award, was named to the MIT Technology Review Innovators Under 35 (TR35) Asia Pacific, recognized as a Materials Research Society (MRS) Early Career Distinguished Presenter, awarded the Sammy Kuo Award in Neuroscience, and honored as a finalist for the Regeneron Prize for Creative Innovation.

杨笑博士自2025年以来担任约翰霍普金斯大学生物医学工程系助理教授，同时是转化组织工程中心和微生理系统中心的成员。在此之前，杨笑博士曾在斯坦福大学担任吴蔡神经科学研究院跨学科博士后学者。她在哈佛大学获得了化学博士学位，并在北京大学获得了化学学士学位。她的实验室致力于开发用于脑机接口和再生医学的仿生及艺术启发的生物电子技术。杨博士的研究成果发表在Nature Biotechnology、Nature Biomedical Engineering、Nature Materials、Nature Reviews Bioengineering等学术期刊上。她获得了马里兰干细胞研究基金启动奖，入选麻省理工科技评论亚太地区35岁以下科技创新者（TR35），被评为材料研究学会（MRS）青年职业杰出演讲者，获得斯坦福大学神经科学Sammy Kuo奖，并成为Regeneron“创意创新奖”的决赛入围者。

【主持人】

熊泽

上海科技大学

【研讨嘉宾】

杨伟峰

苏黎世联邦理工学院

肖潇

新加坡国立大学