论文标题：Immunometabolism: a new dimension in immunotherapy resistance

期刊： Frontiers of Medicine

作者：Chaoyue Xiao, Wei Xiong, Yiting Xu, Ji’an Zou, Yue Zeng, Junqi Liu, Yurong Peng, Chunhong Hu, Fang Wu

发表时间：15 Aug 2023

DOI：10.1007/s11684-023-1012-z

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中南大学吴芳团队在Frontiers of Medicine发表综述论文《免疫代谢：免疫治疗耐药性研究的新维度》（Immunometabolism: a new dimension in immunotherapy resistance）。本文从免疫细胞代谢重编程的新维度，阐述了肿瘤微环境中不同免疫细胞的代谢特点及相关代谢干预策略，探讨了免疫代谢信号通路，为解决免疫治疗耐药问题提供了理论依据。

Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and revolutionized the paradigm of tumor treatment, while substantial patients remain unresponsive or develop resistance to ICIs as a single agent, which is traceable to cellular metabolic dysfunction. Although dysregulated metabolism has long been adjudged as a hallmark of tumor, it is now increasingly accepted that metabolic reprogramming is not exclusive to tumor cells but is also characteristic of immunocytes. Correspondingly, people used to pay more attention to the effect of tumor cell metabolism on immunocytes, but in practice immunocytes interact intimately with their own metabolic function in a way that has never been realized before during their activation and differentiation, which opens up a whole new frontier called immunometabolism. The metabolic intervention for tumor-infiltrating immunocytes could offer fresh opportunities to break the resistance and ameliorate existing ICI immunotherapy, whose crux might be to ascertain synergistic combinations of metabolic intervention with ICIs to reap synergic benefits and facilitate an adjusted anti-tumor immune response. Herein, we elaborate potential mechanisms underlying immunotherapy resistance from a novel dimension of metabolic reprogramming in diverse tumor-infiltrating immunocytes, and related metabolic intervention in the hope of offering a reference for targeting metabolic vulnerabilities to circumvent immunotherapeutic resistance.

免疫检查点抑制剂（ICIs）已展现出无与伦比的临床疗效，并彻底改变了肿瘤治疗的范式，然而，大量患者对单独使用ICIs并无应答，或会产生耐药性，这可归因于细胞代谢功能障碍。尽管代谢失调长期以来被认为是肿瘤的一个重要特征，但如今越来越多的人认为代谢重编程不仅限于肿瘤细胞，也是免疫细胞的特征。过去人们更关注肿瘤细胞代谢对免疫细胞的影响，但实际上，免疫细胞在其激活和分化过程中与其自身的代谢功能紧密相互作用，这开辟了一个全新的领域，即免疫代谢。对肿瘤浸润免疫细胞进行代谢干预，可能为克服耐药性和改善现有的ICI免疫治疗提供新的契机，其关键可能是确定代谢干预与ICIs的协同联合方案，以获取协同效益并促进适应性抗肿瘤免疫反应的产生。本研究从不同肿瘤浸润免疫细胞的代谢重编程这一新维度，阐述了免疫治疗耐药的潜在机制，以及相关的代谢干预措施，以期为针对代谢弱点来规避免疫治疗耐药提供参考依据。

期刊介绍

Frontiers of Medicine专注于发表临床医学和基础医学领域的最新研究成果，旨在通过全球医疗专业人员之间的交流促进健康和医疗保健的发展。该刊采用严格的同行评审和编辑流程，确保发表的文章的科学准确性、新颖性和重要性。

原文信息

标题

Immunometabolism: a new dimension in immunotherapy resistance

作者

Chaoyue Xiao¹, Wei Xiong², Yiting Xu³, Ji’an Zou³, Yue Zeng¹, Junqi Liu¹, Yurong Peng¹, Chunhong Hu^1,4, Fang Wu^1,4,5,6

机构

1. Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha 410011, China

2. NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China

3. Xiangya School of Medicine, Central South University, Changsha 410013, China

4. Hunan Cancer Mega-Data Intelligent Application and Engineering Research Centre, Changsha 410011, China

5. Hunan Key Laboratory of Early Diagnosis and Precision Therapy in Lung Cancer, The Second Xiangya Hospital, Central South University, Changsha 410011, China

6. Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, China

通讯作者

Fang Wu

引用这篇文章

Chaoyue Xiao, Wei Xiong, Yiting Xu, Ji’an Zou, Yue Zeng, Junqi Liu, Yurong Peng, Chunhong Hu, Fang Wu. Immunometabolism: a new dimension in immunotherapy resistance. Front. Med., 2023, 17(4): 585–616 https://doi.org/10.1007/s11684-023-1012-z

https://journal.hep.com.cn/fmd/EN/10.1007/s11684-023-1012-z

https://link.springer.com/article/10.1007/s11684-023-1012-z

感谢作者对Frontiers of Medicine的信任和支持。

《前沿》系列英文学术期刊

由教育部主管、高等教育出版社主办的《前沿》（Frontiers）系列英文学术期刊，于2006年正式创刊，以网络版和印刷版向全球发行。系列期刊包括基础科学、生命科学、工程技术和人文社会科学四个主题，是我国覆盖学科最广泛的英文学术期刊群，其中12种被SCI收录，其他也被A&HCI、Ei、MEDLINE或相应学科国际权威检索系统收录，具有一定的国际学术影响力。系列期刊采用在线优先出版方式，保证文章以最快速度发表。

中国学术前沿期刊网

http://journal.hep.com.cn