南方科技大学郭红卫研究组宣布他们发现了乙烯受体感知内质网氧化还原状态。这一研究成果发表在2026年4月28日出版的国际学术期刊《细胞》上。

该研究团队发现乙烯受体通过管腔定位的分子间二硫键来感知内质网的氧化还原状态。内质网还原性应激，而不是乙烯，破坏受体的二硫连接二聚体，抑制其功能，从而激活下游乙烯信号。

此外，通过内质网氧化还原转移调节受体乙烯响应1 （ETR1）中二硫键的形成支持植物在缺氧和光形态形成过程中的恢复能力。最后，他们的研究结果表明，感知内质网氧化还原可能是一种祖先受体功能，早于乙烯生物合成的实质性出现。这项研究揭示了细胞器稳态和激素信号之间更深层次的联系。

据悉，内质网（ER）氧化还原稳态对内质网功能至关重要，并与多种人类疾病有关，但其在植物中的生理意义在很大程度上仍然未知。乙烯是一种关键的植物激素，在内质网被感知和转导，这表明内质网和乙烯信号之间的联系尚未被充分探索。

附：英文原文

Title: Sensing endoplasmic reticulum redox state by ethylene receptors

Author: Dongdong Hao, Zhina Xiao, Wei Yan, Chenliang Pan, Yanting Yang, Wen Song, Zhiren Chen, Ying Xing, Lian Jin, Yang Peng, Yuping Qiu, Kai Jiang, Xing Wen, Kai Huang, Shi Xiao, Haodong Chen, Hongwei Guo

Issue&Volume: 2026-04-28

Abstract: Endoplasmic reticulum (ER) redox homeostasis is critical for ER functionality and is implicated in various human diseases, yet its physiological significance in plants remains largely elusive. Ethylene, a key phytohormone, is perceived and transduced at the ER, suggesting an underexplored connection between the ER and ethylene signaling. Here, we show that ethylene receptors sense the ER redox state via lumen-localized intermolecular disulfide bonds. ER reductive stress, rather than ethylene, disrupts the disulfide-linked dimers of the receptors, repressing their function and thereby activating downstream ethylene signaling. Moreover, modulating disulfide bond formation in the receptor ETHYLENE RESPONSE 1 (ETR1) through ER redox shifts supports plant resilience under hypoxia and during photomorphogenesis. Finally, our findings suggest that sensing ER redox may be an ancestral receptor function, predating the substantial emergence of ethylene biosynthesis. This study illuminates a deeper nexus between organelle homeostasis and hormone signaling.

DOI: 10.1016/j.cell.2026.04.004

Source: https://www.cell.com/cell/abstract/S0092-8674(26)00393-4