牛津大学Francesco Licausi小组近日取得一项新成果。经过不懈努力，他们的论文发现了H₂O₂重新利用植物的O₂感知来调节缺氧后的反应。该研究于2026年4月22日发表于国际一流学术期刊《自然》杂志上。

在这里，该课题组研究人员报道ERFVIIs在潜水后恢复中也很重要，通过ROS介导的PCO抑制在再氧化时保持稳定。稳定的ERFVII保留在缺氧反应启动子处，成为典型缺氧标记基因的抑制因子，但上调参与ROS稳态和氧化应激保护的基因。他们的研究结果表明，PCOs和ERFVII通过潜水诱导的缺氧和潜水胁迫，整合来自氧气和ROS的信号来协调ERFVII的稳定性，从而促进植物的生存和恢复。

据了解，了解植物对洪水的分子反应对于提高抗灾能力的策略至关重要。植物通过降低植物半胱氨酸氧化酶（PCO）活性来应对淹没诱导的低氧（缺氧），从而稳定第七组乙烯反应因子（ERFVIIs），这是代谢和解剖适应反应的主要调节因子。在水下快速再氧化诱导活性氧（ROS）的产生和代谢重构的爆发；然而，植物如何减轻这种缺氧后应激以促进水下恢复仍是未知的。

附：英文原文

Title: H2O2 repurposes plant O2 sensing to regulate post-hypoxia responses

Author: Akter, Salma, Perri, Monica, Lavilla-Puerta, Mikel, Lichtenauer, Sophie, He, Yuming, Shukla, Vinay, Carbonare, Laura Dalle, Telara, Yuri, Zhang, Daai, Ferretti, Beatrice, Gunawardana, Dona M., Myers, William K., Barreto, Pedro, Giuntoli, Beatrice, Schwarzlnder, Markus, Flashman, Emily, Licausi, Francesco

Issue&Volume: 2026-04-22

Abstract: Understanding plant molecular responses to flooding is crucial for strategies to increase resilience. Plants respond to submergence-induced low oxygen (hypoxia) through decreased plant cysteine oxidase (PCO) activity, which stabilizes group VII ethylene response factors (ERFVIIs), master regulators of metabolic and anatomic acclimation responses1,2,3,4. Rapid reoxygenation on desubmergence induces a burst of reactive oxygen species (ROS) generation and metabolic reconfiguration5,6; however, how plants mitigate this post-hypoxic stress to facilitate submergence recovery has remained unknown. Here we report that ERFVIIs are also important in post-submergence recovery, remaining stable upon reoxygenation through ROS-mediated PCO inhibition. Stabilized ERFVIIs are retained at hypoxia-responsive promoters, becoming repressors of typical hypoxia marker genes but upregulators of genes involved in ROS homeostasis and oxidative stress protection. Our findings suggest that PCOs and ERFVIIs integrate signals from both oxygen and ROS to coordinate ERFVII stability through submergence-induced hypoxia and desubmergence stress to promote plant survival and recovery.

DOI: 10.1038/s41586-026-10366-1

Source: https://www.nature.com/articles/s41586-026-10366-1