加州大学圣地亚哥分校Joseph G. Gleeson团队的一项最新研究提出了感觉和交感神经节的发育组织。这一研究成果于2026年4月1日发表在国际顶尖学术期刊《自然》上。

利用小鼠的CRISPR条形码和人类的马赛克变体条形码分析，该团队证明了神经嵴祖细胞沿着背尾轴的双侧祖细胞克隆扩散，但感觉和交感谱系之间的克隆重叠有限。镶嵌变异的计算模型表明，大多数神经嵴细胞在分层前表现出强烈的命运限制。鹌鹑胚胎的实时成像进一步显示成纤维细胞生长因子依赖的神经嵴细胞在多个轴向水平上的背侧分散。这些发现支持了一种模型，即神经嵴命运偏差主要出现在神经管中，只有一小部分分层祖细胞保留了产生感觉和交感衍生物的多能性。

据介绍，神经嵴产生了广泛的细胞类型，这些细胞类型在全身范围内迁移，并计划在多个组织中繁殖。然而，神经嵴衍生物谱系之间的关系仍然不清楚，神经嵴细胞从神经管剥离的程度仍然存在争议。

附：英文原文

Title: Developmental organization of sensory and sympathetic ganglia

Author: Vong, Keng Ioi, Alvarez, Yanina D., Zhang, Qingquan, Weng, Jiaming, Noel, Geoffroy, Barton, Scott T., Chung, Changuk, Howarth, Robyn, Meave, Naomi, Jiwani, Fiza, Patarlapalli, Sai B., Yao, Fenyong, Zhu, Fugui, Barrows, Chelsea, Patel, Arzoo, Wang, Jian Xiong, Chi, Neil C., Kingsmore, Stephen F., White, Melanie D., Yang, Xiaoxu, Gleeson, Joseph G.

Issue&Volume: 2026-04-01

Abstract: The neural crest generates a broad spectrum of cell types that migrate across the body plan to populate multiple tissues1. However, the relationship between lineages of neural crest derivatives remains unclear, and the extent to which neural crest cells delaminated from the neural tube have specified fates remains debated. Here, leveraging CRISPR barcoding in mice and mosaic variant barcode analysis in humans, we demonstrate robust bilateral progenitor clonal spread of neural crest progenitors along the rostrocaudal axis but limited clonal overlap between sensory and sympathetic lineages. Computational modelling of mosaic variants suggests that most neural crest cells show strong fate restriction before delamination. Real-time imaging of quail embryos further shows a fibroblast-growth-factor-dependent rostrocaudal dispersion of neural crest cells across multiple axial levels. These findings support a model in which neural crest fate bias predominantly emerges within the neural tube, with only a minor subset of delaminated progenitors retaining multipotency to generate both sensory and sympathetic derivatives.

DOI: 10.1038/s41586-026-10313-0

Source: https://www.nature.com/articles/s41586-026-10313-0