巴黎索邦大学Nicolas Renier团队取得一项新突破。他们提出了小鼠出生后大脑血管形成的时空动态。相关论文于2026年4月14日发表于国际顶尖学术期刊《细胞》杂志上。
为了解决这一时空问题，该团队开发了一种光片对齐的无主题大脑注释发育图谱（LAMBADA），这是一种用于记录和注释光学清除的发育中的无主题大脑的高时间分辨率的工具，通过对齐的空间转录组学进行了丰富。利用这种阻力，该课题组研究人员确定了出生后脑血管发育的三个不同的全脑阶段：(1)以典型转录组特征为特征的等长扩张阶段；(2)与神经元成熟和突触发生相一致的区域特化阶段；(3)以血管网络和突触稳定为标志的细化阶段。研究小组通过将血管重塑与空间转录组基因表达联系起来，描绘了这些阶段的分子和结构机制。该图谱为研究发育性神经血管相互作用提供了基础，并为小鼠产后脑发育研究提供了参考。
据介绍，出生时脑血管结构不成熟，并在出生后经历了显著的重塑和扩张。然而，血管化如何在整个大脑中进行，以将体积增长与神经元回路成熟结合起来尚不清楚。
附：英文原文
Title: The spatiotemporal dynamics of postnatal vascularization in the mouse brain
Author: Elisa de Launoit, Sophie Skriabine, Etienne Doumazane, Mathilde Bizou, Rémi Pommé, Gabrièle Lienhard, Domitille Rajot, Alina Mikhailenko, Alba Vieites-Prado, Mathilde Lannes, Natalia Fabiano, Louise Mathé, Gael Cagnone, Laura Mouton, Mathieu D. Santin, Séverine Candelier, Patricia Gaspar, Charly V. Rousseau, Alexandre Dubrac, Nicolas Renier
Issue&Volume: 2026-04-14
Abstract: The structure of the cerebral vasculature is immature at birth and undergoes significant postnatal remodeling and expansion. However, how vascularization progresses throughout the brain to integrate volumetric growth with neuronal circuit maturation is unclear. To address this spatiotemporally, we developed a light-sheet-aligned mouse brain annotated developmental atlas (LAMBADA)—a resource for registering and annotating optically cleared developing mouse brains with high temporal resolution, enriched by aligned spatial transcriptomics. Using this resource, we identified three distinct, brain-wide phases of postnatal cerebral vascular development: (1) an isometric expansion phase characterized by canonical transcriptomic signatures; (2) a regional specialization phase coinciding with neuronal maturation and synaptogenesis; and (3) a refinement phase marked by the stabilization of vascular networks and synapses. We delineated the molecular and structural mechanisms underlying these phases by correlating vascular remodeling with spatial transcriptomic gene expression. This atlas provides a foundation for studying developmental neurovascular interactions and serves as a resource for murine postnatal brain development research.
DOI: 10.1016/j.cell.2026.03.013
Source: https://www.cell.com/cell/abstract/S0092-8674(26)00280-1