在这项研究中，该研究团队发现，SCI多样化通过与基因水生生活方式相关的水平转移有效地发生：从溶解细胞中释放的DNA被天然能力强的弧菌吸收，并整合到SCI阵列的第一个位置，这是强表达的主要位点，在那里它可以抵抗噬菌体和潜在的其他威胁。
据介绍，细菌通常通过共享增强防御能力的基因，在病毒攻击和环境压力下存活下来。霍乱病原体霍乱弧菌携带一种静止染色体整合子（SCI），这是一种遗传元件，包含数百个大多数无启动子的基因磁带，其中约10%编码抗病毒系统。盒式磁带被认为在压力下会重新洗牌到有利的第一阵列位置，但大流行霍乱弧菌的SCI在60多年来一直保持不变。
附：英文原文
Title: Competence-mediated DNA uptake diversifies Vibrio cholerae sedentary chromosomal integrons
Author: Laurie Righi, Sandrine Stutzmann, Loriane Bader, Alexandre Lemopoulos, Melanie Blokesch
Issue&Volume: 2026-04-09
Abstract: Bacteria often survive viral attack and environmental stress by sharing genes that enhance their defenses. The cholera pathogen Vibrio cholerae carries a sedentary chromosomal integron (SCI), a genetic element containing hundreds of mostly promoterless gene cassettes, about 10% of which encode antiviral systems. Cassettes are thought to reshuffle under stress to the favorable first array position, yet the SCI in pandemic V. cholerae has remained static for more than 60 years. In this study, we show that SCI diversification efficiently occurs by horizontal transfer linked to the genus’s aquatic lifestyle: DNA released from lysed cells is taken up by naturally competent vibrios and integrated into the first position of the SCI array, the primary site of strong expression, where it confers resistance to phage and potentially other threats.
DOI: aed0645
Source: https://www.science.org/doi/10.1126/science.aed0645