中国科学院深圳先进技术研究院集成所徐天添团队联合中国医学科学院阜外医院潘湘斌团队取得一项新突破。他们通过磁流体实现左心耳长期无血栓封堵。2026年3月4日出版的《自然》发表了这项成果。

在这里，该研究团队提出了一种个性化的、完全封堵策略的LAAO主题磁流体，适用于所有类型的LAAs。磁流体可以从心导管注入LAAs。在有足够磁场的情况下，磁流体可以抵抗高速血流。磁流体与血液中的水在几分钟内就能沉淀成磁凝胶。该研究团队通过猪动物模型进一步证实了磁凝胶在体内超过10个月的长期稳定性和生物相容性。在任何猪中均未观察到与器械相关的血栓或磁漏。Watchman封堵器上形成的心内膜粗糙且不完整，易形成血栓。其倒刺结构不可避免会造成心肌损伤。在磁凝胶上形成的心内膜光滑、牢固且无血栓形成。磁凝胶与LAA之间未见裂缝，心肌未见损伤。这些发现可能为长期无血栓LAAO提供了一个有希望的临床策略。

据悉，由于实体封堵器与左心耳附件（LAA）之间的不相容，器械周围泄漏和器械相关血栓仍然是当前左心耳封堵术（LAAO）的主要挑战。

附：英文原文

Title: Long-term thrombus-free left atrial appendage occlusion via magnetofluids

Author: Wang, Shu, Ju, Wenhao, Zhuang, Donglin, Chen, Zhecheng, Zhao, Dongliang, Huang, Shunyuan, Wang, Tiankuo, Cai, Mingxue, Liu, Siyu, Fu, Shixiong, Cheng, Zhiguo, Tan, Wenchang, Pan, Xiangbin, Wu, Xinyu, Wang, Shouzheng, Xu, Tiantian

Issue&Volume: 2026-03-04

Abstract: Peri-device leak and device-related thrombus1 remain key challenges of current left atrial appendage occlusion (LAAO)2 owing to the incompatibility between the solid occluder and the left atrial appendage (LAA). Here we propose a personalized and complete LAAO using magnetofluids that is suitable for all types of LAAs. Magnetofluids can be injected into LAAs from cardiac catheters. In the presence of a sufficient magnetic field, magnetofluids can resist high-speed blood flow. Magnetofluids can precipitate into magnetogels in contact with water in the blood within only a few minutes. We further confirmed the long-term resilience and biocompatibility of the magnetogel over 10months in a pig model in vivo. Neither device-related thrombus nor magnetogel leakage was observed in any pigs. The endocardium formed on the Watchman occluder was rough and incomplete, predisposing to thrombosis. Myocardial injuries were unavoidable due to the barbs of the Watchman occluder. The endocardium formed on our magnetogel was smooth, firm and thrombus-free. No crevice was observed between our magnetogel and the LAA, and no injury was caused to the myocardium. These findings may offer a promising clinical strategy for long-term thrombus-free LAAO.

DOI: 10.1038/s41586-025-10091-1

Source: https://www.nature.com/articles/s41586-025-10091-1