广州医科大学刘兴国团队近日取得一项新成果。经过不懈努力，他们的论文发现了包封线粒体移植可减轻线粒体和帕金森病模型的功能障碍。该项研究成果发表在2026年3月18日出版的《细胞》上。
该研究团队提出了一种线粒体移植方法，将线粒体高效地输送到小鼠和猴子的细胞和组织中，该方法基于红细胞质膜衍生的囊泡包封线粒体。包封线粒体治疗补充了线粒体DNA的缺失、缺失或突变，从而挽救了线粒体疾病患者源性细胞中相关的生物能量和生化缺陷。
此外，线粒体胶囊分别挽救了Dguok-/-和Ndufs4-/-小鼠模型中的线粒体DNA耗竭综合征和Leigh综合征。
此外，在帕金森病的无主题模型中，线粒体胶囊挽救了神经元丢失，改善了运动技能，并恢复了受影响大脑区域的线粒体功能。他们的研究证明了这种线粒体胶囊治疗线粒体疾病的潜力，并提出了再生医学中的“细胞器治疗”策略。
据悉，线粒体移植在治疗线粒体疾病方面具有巨大的潜力。然而，如何有效地将外源线粒体输送到体细胞或组织中仍未得到解决。
附：英文原文
Title: Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models
Author: Shiwei Du, Qi Long, Yanshuang Zhou, Jiangqin Fu, Hao Wu, Liang Yang, Yaohang Xie, Yingzhe Ding, Maolei Zhang, Jingyi Guo, Mengfei Wang, Jiajun Lin, Mingli Hu, Jian Zhang, Deyang Yao, Wei Li, Feixiang Bao, Ge Xiang, Yi Wu, Yile Huang, Haozhao Liang, Rui Wang, Heying Li, Baodan Chen, Chong Li, Junwei Wang, Jiwei Zhang, Dajiang Qin, Jianwei Sun, Yun Zhu, Fei Sun, Wuming Wang, Gang Lu, Wai-Yee Chan, Hui Zhao, Chenli Liu, Xingguo Liu
Issue&Volume: 2026-03-18
Abstract: Mitochondrial transplantation holds significant potential for the treatment of mitochondrial diseases. However, how to efficiently deliver exogenous mitochondria to somatic cells or tissues remains unresolved. We present a mitochondrial transplantation approach to deliver mitochondria into the cells and tissues of mice and monkeys with high efficiency, based on encapsulating mitochondria with vesicles derived from the plasma membrane of erythrocytes. Treatment with encapsulated mitochondria complemented the loss, deletion, or mutation of mitochondrial DNA, thereby rescuing the associated bioenergetic and biochemical defects in patient-derived cells with mitochondrial disorders. Furthermore, mitochondrial capsules rescued the mitochondrial DNA depletion syndrome and Leigh syndrome in Dguok/ and Ndufs4/ mouse models, respectively. Moreover, in a mouse model of Parkinson’s disease, mitochondrial capsules rescued neuron loss, improved motor skills, and restored mitochondrial function in the affected brain regions. Our study demonstrates the potential of this mitochondrial capsule as a treatment for mitochondrial disorders and proposes an “organelle therapy” strategy in regenerative medicine.
DOI: 10.1016/j.cell.2026.02.023
Source: https://www.cell.com/cell/abstract/S0092-8674(26)00230-8