昌平实验室刘河生教授团队近日取得一项新成果。经过不懈努力，他们揭示了帕金森病是一种躯体认知行为网络障碍。相关论文于2026年2月4日发表于国际顶尖学术期刊《自然》杂志上。

为了研究扫描在PD病理生理和治疗（药物、深部脑刺激（DBS）、经颅磁刺激（TMS）和MRI引导的聚焦超声刺激（MRgFUS））中的作用，研究小组建立了一个大型(n=863)、多模式、多干预临床影像数据集。静息状态功能连通性显示，黑质和所有PD - DBS靶点（丘脑下核区、半球苍白区和腹侧中间区）选择性地连接到SCAN，而不是连接到效应特异性运动区。重要的是，PD的特征是SCAN和下皮层之间的特异性超连接。

因此，课题组人员跟踪了6个PD队列，分别接受DBS、TMS、MRgFUS和左旋多巴治疗，主题是精确静息状态功能连接和皮质电成像记录。有效的治疗减少了扫描到皮层下的超连通性。针对扫描区而不是效应区，TMS治疗的效果翻了一番。当目标更接近丘脑扫描的甜蜜点时，聚焦超声治疗的益处增加。因此，扫描超连接是PD病理生理学的核心，其缓解是成功的神经调节的标志。靶向功能明确的皮层下扫描节点可能会改善现有的治疗方法（DBS, MRgFUS），而皮层扫描靶点为PD提供了有效的无创或微创神经调节。

研究人员表示，帕金森病（PD）是一种无法治愈的神经系统疾病，通常以睡眠障碍和躯体症状开始，逐渐发展为全身运动和认知症状。躯体认知行动网络（SCAN）被认为通过协调芳香、器官生理和全身运动计划与行为动机来控制动作执行，其功能障碍可能是PD临床表现多样化的一个因素。

附：英文原文

Title: Parkinson’s disease as a somato-cognitive action network disorder

Author: Ren, Jianxun, Zhang, Wei, Dahmani, Louisa, Gordon, Evan M., Li, Shenshen, Zhou, Ying, Long, Yang, Huang, Jianting, Zhu, Yafei, Guo, Ning, Jiang, Changqing, Zhang, Feng, Bai, Yan, Wei, Wei, Wu, Yaping, Bush, Alan, Vissani, Matteo, Wei, Luhua, Oehrn, Carina R., Morrison, Melanie A., Zhu, Ying, Zhang, Chencheng, Hu, Qingyu, Yin, Yilin, Cui, Weigang, Fu, Xiaoxuan, Zhang, Ping, Wang, Weiwei, Ji, Gong-Jun, He, Ji, Wang, Kai, Fan, Dongsheng, Wang, Zhaoxia, Kimberley, Teresa, Little, Simon, Starr, Philip A., Richardson, Robert Mark, Li, Luming, Wang, Meiyun, Wang, Danhong, Dosenbach, Nico U. F., Liu, Hesheng

Issue&Volume: 2026-02-04

Abstract: Parkinson’s disease (PD) is an incurable neurological disorder that often begins insidiously with sleep disturbances and somatic symptoms, progressing to whole-body motor and cognitive symptoms1,2,3,4,5. Dysfunction of the somato-cognitive action network (SCAN)—which is thought to control action execution6,7 by coordinating arousal, organ physiology and whole-body motor plans with behavioural motivation—is a potential contributor to the diverse clinical manifestations of PD. To investigate the role of the SCAN in PD pathophysiology and treatments (medications, deep-brain stimulation (DBS), transcranial magnetic stimulation (TMS) and MRI-guided focused ultrasound stimulation (MRgFUS)), we built a large (n=863), multimodal, multi-intervention clinical imaging dataset. Resting-state functional connectivity revealed that the substantia nigra and all PD DBS targets (subthalamic nucleus, globus pallidus and ventral intermediate thalamus) are selectively connected to the SCAN rather than to effector-specific motor regions. Importantly, PD was characterized by specific hyperconnectivity between the SCAN and the subcortex. We therefore followed six PD cohorts undergoing DBS, TMS, MRgFUS and levodopa therapy using precision resting-state functional connectivity and electrocorticography recording. Efficacious treatments reduced SCAN-to-subcortex hyperconnectivity. Targeting the SCAN instead of effector regions doubled the efficacy of TMS treatments. Focused ultrasound treatment benefits increased when the target was closer to the thalamic SCAN sweet spot. Thus, SCAN hyperconnectivity is central to PD pathophysiology and its alleviation is a hallmark of successful neuromodulation. Targeting functionally defined subcortical SCAN nodes may improve existing therapies (DBS, MRgFUS), whereas cortical SCAN targets offer effective non-invasive or minimally invasive neuromodulation for PD.

DOI: 10.1038/s41586-025-10059-1

Source: https://www.nature.com/articles/s41586-025-10059-1