近日，中国科学院长春应用化学研究所逯乐慧团队报道了碳配位钴电化学纳米平台能够在体内选择性监测胶质母细胞瘤浸润脑中的神经化学失调。相关论文于2026年2月3日发表在《美国化学会志》上。

纵向监测脑胶质瘤（GBM）进展过程中的神经化学失调，对于阐明肿瘤-神经元相互作用及推进神经保护策略至关重要。然而，现有方法在复杂的肿瘤微环境中存在时间分辨率不足、空间精度有限及操作稳定性欠佳等问题。

研究组提出一种采用碳配位过渡金属纳米催化剂（CoC_x@C）的微电极传感平台，用于对神经功能关键调节因子多巴胺（DA）进行原位高保真追踪。该设计的配位结构能促进快速、选择性的多电子DA氧化过程，同时其调控的d带中心可最大限度减少非特异性界面吸附，使检测灵敏度较传统电极提升278倍，选择性提高333倍。通过该平台对多模型进行纵向DA追踪，揭示了脑胶质瘤相关神经功能障碍的新机制。该工作首次为神经递质介导的肿瘤-神经元相互作用提供了电化学证据，并为癌症神经科学及其他相关研究提供了可靠工具。

附：英文原文

Title: Carbon-Coordinated Cobalt Electrochemical Nanoplatform Enables in Vivo Selective Monitoring of Neurochemical Dysregulation in Glioblastoma-Infiltrated Brain

Author: Yongqi Cheng, Yan Li, Jun Da, Yanlan Liu, Chen Liu, Lehui Lu

Issue&Volume: February 3, 2026

Abstract: Longitudinal monitoring of neurochemical dysregulation during glioblastoma (GBM) progression is essential for elucidating tumor–neuron interactions and advancing neuroprotective strategies. Current methods, however, are limited by insufficient temporal resolution, spatial precision, and operational stability in the complex tumor microenvironment. We present a microelectrode sensing platform featuring carbon-coordinated transition metal nanocatalysts (CoCx@C) for in situ, high-fidelity tracking of dopamine (DA), a key modulator of neurological function. The engineered coordination structure facilitates rapid, selective multielectron DA oxidation, while its modulated d-band center minimizes nonspecific interfacial adsorption, yielding 278-fold sensitivity and 333-fold selectivity improvements over conventional electrodes. Longitudinal DA tracking across multiple models with this platform reveals novel insights into GBM-associated neural dysfunction. This work provides the first electrochemical evidence of neurotransmitter-mediated tumor–neuron interplay and offers a robust tool for cancer neuroscience investigations and beyond.

DOI: 10.1021/jacs.5c14261

Source: https://pubs.acs.org/doi/abs/10.1021/jacs.5c14261