四川大学沈颉飞课题组取得一项新突破。他们提出了周围神经系统损伤反应的衰老相关变化。相关论文发表在2026年2月24日出版的《神经科学通报》杂志上。

周围神经损伤（PNI）显著损害患者的生活质量，老年人由于神经元损伤反应和修复能力的衰老相关下降而经历特别严重的后果。损伤信号的产生和传递、轴突的断裂、再生的启动、再生轴突的伸长以及这些轴突随后的再神经支配等过程都受到衰老的显著影响。这些改变与线粒体功能、神经元运输系统、持续炎症环境和各种微环境非神经元细胞的变化密切相关。因此，本文综合了衰老在PNI后神经系统多方面调控中的关键作用，并强调了信号通路中有前景的分子调控机制。

此外，它确定了未来研究的关键领域，包括年龄相关损伤反应的未解决问题，药物干预的潜在目标，以及值得研究和开发的新兴治疗策略。

附：英文原文

Title: Aging-Related Changes in the Injury Response of the Peripheral Nervous System

Author: Cen, Yue-Yan, Wang, Mu-Yun, Song, Qin-Xuan, Gao, Xin-Lin, Zhou, Cheng, Li, Chun-Jie, Liu, Fei, Zhang, Yan-Yan, Shen, Jie-Fei

Issue&Volume: 2026-02-24

Abstract: Peripheral nerve injury (PNI) significantly impairs patients’ quality of life, with elderly individuals experiencing particularly severe consequences due to aging-related declines in neuronal injury response and repair capabilities. Processes of the generation and transmission of injury signals, axonal disruption, initiation of regeneration, and the elongation of regenerating axons, as well as the subsequent reinnervation by these axons, are all significantly influenced by aging. These alterations are closely associated with changes in mitochondrial function, neuronal transport systems, a persistent inflammatory milieu, and various microenvironmental non-neuronal cells. Therefore, this review synthesized the pivotal role of aging in the multifaceted regulation of the nervous system following PNI and highlighted promising molecular regulatory mechanisms in the signaling pathways. Furthermore, it identified critical areas for future research, including unresolved questions in age-associated injury responses, potential targets for pharmacological intervention, and emerging therapeutic strategies meriting consideration for research and development.

DOI: 10.1007/s12264-025-01564-4

Source: https://link.springer.com/article/10.1007/s12264-025-01564-4