加州大学Jun Chen团队近日取得一项新成果。经过不懈努力，他们提出了血流动力学驱动的磁弹性血管移植在狭窄诊断中的应用。这一研究成果于2026年2月10日发表在国际顶尖学术期刊《自然—生物技术》上。

在这里，课题组报告了一种用于植入后狭窄诊断的磁弹性血管移植物（MVG），它是血流动力学驱动的，生物相容性和防水的。它通过将动脉血流动力学转换为高保真的电信号，实现了对狭窄的无线、实时和持续诊断。通过显微外科吻合在大鼠和猪的股动脉中进行了体内试验，并可大规模地制造出具有可切离直径的MVG。吻合的血管内皮细胞恢复血流，并通过人工智能辅助分析确定诱发狭窄的位置和严重程度。

此外，一项为期4个月的大鼠体内研究证实了MVG在宿主体内的稳定性和生物相容性，没有明显的不良免疫反应迹象。MVG有望推进现有的血管移植解决方案，改善血管疾病的管理。

据了解，传统的血管移植狭窄诊断方法，包括X线血管造影、磁共振成像和多普勒超声，虽然精度很高，但繁琐，间歇性使用，往往不能及时发现狭窄，导致只有在明显狭窄后才能诊断。

附：英文原文

Title: Hemodynamics-driven magnetoelastic vascular grafts for stenosis diagnosis

Author: Chen, Guorui, Chung, Tzuchun, Liu, Zeyang, Li, Yan-Ruide, Scott, Kamryn, Zhao, Xun, Carol, Jarod, Park, Soomin, Zhou, Yihao, Kim, Wi Jin, Ge, Xinyang, Colby, Geoffrey P., Li, Song, Chen, Jun

Issue&Volume: 2026-02-10

Abstract: Conventional approaches for vascular graft stenosis diagnostics, including X-ray angiography, magnetic resonance imaging and Doppler ultrasound, although highly accurate, are cumbersome, used intermittently and often do not detect stenosis early enough, leading to diagnosis only after substantial narrowing. Here we report a magnetoelastic vascular graft (MVG) for post-implantation stenosis diagnosis that is hemodynamics-driven, biocompatible and waterproof. It enables wireless, real-time and continuous diagnosis of stenosis by converting arterial hemodynamics into high-fidelity electrical signals. The MVGs were scalably manufactured with customizable diameters and tested in vivo in the femoral arteries of rats and swine through microsurgical anastomosis. The anastomosed MVGs restored blood flow and identified the location and severity of induced stenosis through artificial intelligence-assisted analysis. Furthermore, a 4-month in vivo study in rats verified the stability and biocompatibility of the MVGs in the host, with no evident signs of an adverse immune response. The MVG is expected to advance existing vascular graft solutions and improve vascular disease management.

DOI: 10.1038/s41587-025-02619-7

Source: https://www.nature.com/articles/s41587-025-02619-7