研究组发现，无母背神经元随着时间的推移而多样化，相关细胞类型的家族作为时间队列而诞生，并通过指定单个细胞类型的空间分子梯度。兴奋性神经元进入一种时间顺序排列，将其进行性出生日期转变为解剖顺序，并需要建立适当的椎板。该团队确定了基本的个体发生原则，将背祖细胞塑造成不同的细胞类型和结构，为感觉运动功能服务。
据介绍，哺乳动物脊髓的背角被组织成层状，每层由不同类型的神经元组成，具有独特的电路连接，在行为中起着特殊的作用。一个突出的问题是，这个组织是如何在发育过程中从一个明显同质的神经祖细胞池中出现的。
附：英文原文
Title: Ontogeny of the spinal cord dorsal horn
Author: Robert Brian Roome, Archana Yadav, Lydia Flores, Amrit K. Puarr, Diana Nardini, Alexander Richardson, Ronald R. Waclaw, Ruth M. Arkell, Vilas Menon, Jane E. Johnson, Ariel J. Levine
Issue&Volume: 2026-01-08
Abstract: The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in behavior. An outstanding question is how this organization emerges during development from an apparently homogeneous pool of neural progenitors. Here, we show that mouse dorsal neurons are diversified by time, with families of related cell types born as temporal cohorts, and by a spatial-molecular gradient that specifies individual cell types. Excitatory neurons settle into a chronotopic arrangement that transforms their progressive birthdates into anatomical order and is required to establish proper laminae. We identified essential ontogenetic principles that shape dorsal progenitors into the diverse cell types and structure that subserve sensorimotor function.
DOI: adx5781
Source: https://www.science.org/doi/10.1126/science.adx5781