近日，中国科学技术大学江海龙团队报道了近红外激活的多光子光催化系统通过CO生成和OH生成进行协同治疗。相关论文于2026年1月27日发表在《德国应用化学》杂志上。

光触发可控一氧化碳释放技术为癌症治疗提供了新思路，但受限于光的组织穿透能力不足以及深部肿瘤微环境中CO释放速率低等问题。

受近红外激活多光子光催化的启发，研究组首次报道了一种新型锌基金属有机框架材料，能够通过联合CO气体疗法与光动力疗法，在深部肿瘤中实现近红外介导的协同治疗。该MOF材料以具有A-π-A构型的V形屈格尔碱衍生物作为有机连接体，协同增强了CO₂吸附能力，从而克服肿瘤中“CO₂浓度不足”的挑战，同时通过近红外驱动的多光子光催化实现高效的内源性CO₂向CO转化。

此外，光生空穴可局域在联苯-4,4'-二甲酸上驱动水氧化产生羟基自由基，从而进一步提升疗效。该研究为设计近红外光驱动光催化系统，实现安全、精准、局域化的CO递送提供了重要进展，为基于CO或联合疗法治疗深部肿瘤开辟了新途径。

附：英文原文

Title: Near-Infrared-Activated Multiphoton Photocatalytic System for Synergistic Therapy via CO Generation and •OH Production

Author: Bo Li, Yunyang Qian, Xiyuan Zhang, Xin Lu, Yifan Huang, Xianshun Sun, Hongping Zhou, Yupeng Tian, Dandan Li, Hai-Long Jiang

Issue&Volume: 2026-01-27

Abstract: Light-triggered controllable carbon monoxide (CO) release represents a promising approach for cancer therapy but is limited by the poor tissue penetration of light and insufficient CO release rates within deep tumor microenvironments. Herein, inspired by near-infrared (NIR)-activated multiphoton photocatalysis, a novel zinc-based metal-organic framework (ZnTBH) is reported, for the first time, to enable effective NIR-mediated synergistic therapy through combined CO gas therapy and photodynamic therapy (PDT) in deep-seated tumors. The engineered MOF integrates a V-shaped Trger's base (TB) derivative with an A-π-A configuration as the organic linker, synergistically enhancing CO2 adsorption to overcome the “dilute CO2” challenge in tumors while enabling efficient endogenous CO2-to-CO conversion via NIR-driven multiphoton photocatalysis. Moreover, the photogenerated holes localize on biphenyl-4,4'-dicarboxylic acid can drive water oxidation to hydroxyl radicals (OH), thereby further improving therapeutic efficacy. This study presents a significant advancement in the design of NIR light-driven photocatalytic systems for safe, precise, and localized CO delivery, offering new opportunities for CO-based or combination therapies in the treatment of deep-seated tumors.

DOI: 10.1002/anie.202524756

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202524756