清华大学齐天从小组在研究中取得进展。他们开发出uORF编码的移动肽引发全身气孔免疫。这一研究成果于2026年1月27日发表在国际顶尖学术期刊《细胞》上。
该研究组观察到，被病原体感染的局部叶片将危险状态传递给未感染的远端系统叶片，并触发它们的气孔关闭，作为一种被称为系统性气孔免疫（SSIM）的全局防御。潜在的移动信号仍然未知。小组报道了上游开放阅读框（uORF）编码的系统性气孔免疫导体（USIC）作为一种远距离移动肽诱导SSIM。在局部叶片中，USIC随着病原体/模式信号的增加而增加，并分泌到外质体中进行长途运输。在系统叶片中，USIC被细胞表面蔗糖诱导的受体激酶1 (SIRK1)-激酶7 （KIN7）受体复合物感知，并诱导METACASPASE 4 （MC4）介导的KIN7切割。KIN7与质子泵/水通道蛋白相关，调节气孔关闭。这项研究揭示了一个系统性的信号机制，即uORF编码的移动信号及其受体途径激活SSIM。
据介绍，高等生物体将外部刺激从感知组织传播到全身，以达到全身反应。在植物中，保护细胞感知病原体并关闭气孔以阻止病原体进入。
附：英文原文
Title: An uORF-encoded mobile peptide sparks systemic stomatal immunity
Author: Changzhen Liu, Qiangsheng Yu, Yunfan Jin, Wei Ma, Jing Li, Tianxue Song, Meng Han, Yi Qian, Qi Xue, Leyi Ke, Yuxin Dong, Congcong Hou, Xuna Wu, Yule Liu, Jizong Wang, Liwen Jiang, Zhizhong Gong, Haiteng Deng, Daoxin Xie, Shengyang He, Zhi John Lu, Susheng Song, Tiancong Qi
Issue&Volume: 2026-01-27
Abstract: Higher organisms spread external stimuli from the perceptive tissues to the whole body to achieve systemic responses. In plants, guard cells sense pathogens and close stomata to prevent their entry. We observed that pathogen-infected local leaves transmit the danger status to uninfected distal systemic leaves and trigger their stomatal closure as a global defense termed systemic stomatal immunity (SSIM). The underlying mobile signals remain unknown. Here, we report that an upstream open reading frame (uORF)-encoded systemic stomatal immune conductor (USIC) acts as a long-distance mobile peptide inducing SSIM. In local leaves, USIC increases upon pathogen/pattern signals and is secreted into the apoplast for long-distance transport. In systemic leaves, USIC is perceived by the cell surface SUCROSE-INDUCED RECEPTOR KINASE 1 (SIRK1)-KINASE 7 (KIN7) receptor complex and induces METACASPASE 4 (MC4)-mediated KIN7 cleavage. KIN7 associates with proton pumps/aquaporins to regulate stomatal closure. This study reveals a systemic signaling mechanism whereby an uORF-encoded mobile signal and its receptor pathway activate SSIM.
DOI: 10.1016/j.cell.2025.12.024
Source: https://www.cell.com/cell/abstract/S0092-8674(25)01437-0