2026年1月27日出版的《细胞》杂志发表了中国科学家的一项最新研究成果。来自北京航空航天大学的常凌乾团队的最新研究提出了一种器官适形的kirigami结构生物电子贴片，用于精确的细胞内递送。
研究组报道了一种用于器官适形kirigami结构电转染（POCKET）的生物电子贴片，该贴片通过参数化实现了高适形，在靶器官上实现了理论上最大的有效覆盖面积。它们的五层POCKET在组织-设备界面形成独特的纳米孔细胞并置配置，在加速有效载荷的细胞内运输的同时，诱导精确、均匀的电穿孔。高输送效率和精确的空间可控性已在多个器官上得到系统验证。口袋介导的治疗递送实现了器官免受累积DNA损伤或缺血再灌注损伤的保护，恢复了器官功能。这项工作提出了一种具有翻译价值的可定制技术，用于在具有挑战性的靶器官中进行精确治疗。
据悉，有效和精确地将药物输送到器官的靶位点是有效治疗疾病的关键。然而，由于缺乏适当的机械和/或材料特性，传统设备在达到临床所需的适形性、空间可控性和效率方面面临着巨大的挑战，特别是对于具有复杂解剖结构的器官。
附：英文原文
Title: An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery
Author: Yuqiong Wang, Lamei Du, Han Wu, Hu Li, Jiaqi Liu, Yongyan Hu, Xinran Jiang, Dedong Yin, Yongcun Hao, Ao Xiao, Yawen Yang, Jingkun Zhou, Long Lin, Feng Chen, Denglin Ye, Yuhui He, Zhixiong Zhao, Baoyu Liu, Kuanming Yao, Xiaohong Wang, Xi Chen, Yihang Tong, Fuqi Yao, Kuan Yang, Hong Sun, Yanzhe Fu, Siqi Wang, Zhaocun Huang, Xinyi Chen, Hao Guo, Shenshen Kong, Shaohua Yang, Wenjing Song, Faheem Ershad, Yang Wang, Li Zhang, Qiuting Zhang, Hao Wu, Ning Li, Wei Rao, Jiebo Li, Li Yang, Xing Chen, Wei Mu, Xinge Yu, Yubo Fan, Cunjiang Yu, Ye Xu, Lingqian Chang
Issue&Volume: 2026-01-27
Abstract: Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy. However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties. Here, we report a bioelectronic patch for organ-conformal, kirigami-structured electro-transfection (POCKET) that features high conformality enabled by parametric customization, achieving a theoretically maximum effective coverage area over the target organ. The four-layered POCKET forms a unique nanopore-cell juxtaposition configuration at the tissue-device interface, which induces precise, uniform electro-perforation while expediting intracellular transport of payloads. The high delivery efficiency and precise spatial controllability have been systematically validated with various organs. POCKET-mediated therapeutic delivery achieved organ protection from accumulated DNA damage or ischemia-reperfusion injury, restoring organ functionalities. This work presents a customizable technique with translational value for precise therapy in challenging target organs.
DOI: 10.1016/j.cell.2025.12.021
Source: https://www.cell.com/cell/abstract/S0092-8674(25)01434-5