肿瘤相关巨噬细胞促进周围神经肿瘤浸润和脊髓修复，这一成果由维罗纳大学Ilaria Decimo团队经过不懈努力而取得。2026年1月26日，国际知名学术期刊《免疫学》发表了这一成果。

在这项研究中，研究小组发现TAMs表达了一种独特的神经生长基因特征。TAMs积极促进肿瘤内的神经生长，并直接促进体外神经突的生长。研究小组发现分泌磷酸化蛋白1 （SPP1）是TAMs驱动的神经生长和mTORC2激活所需的介质。利用TAM-神经生长功能，课题组研究人员探索了TAM的神经再生潜力。在严重完全性脊髓损伤（scSCI）中过继性转移TAMs可增加神经元存活、轴突再生和运动功能恢复。

此外，TAMs还能修复scSCI微环境并重塑囊肿。功能和蛋白质组学分析证实SPP1和神经Rictor是TAMs诱导再生的必要分子介质。他们的数据揭示了TAMs在肿瘤神经支配和神经组织修复中的作用。

据介绍，肿瘤相关巨噬细胞（TAMs）通过促进血管生成、细胞外基质重塑和免疫抑制来促进癌症进展。神经浸润也有助于肿瘤的生长。然而，TAMs在促进肿瘤内神经生长中的作用尚不清楚。

附：英文原文

Title: Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair

Author: Sissi Dolci, Loris Mannino, Eros Rossi, Emanuela Bottani, Francesca Ciarpella, Nicola Piazza, Isabel Karkossa, Marzia Di Chio, Benedetta Savino, Benedetta Lucidi, Giulia Pruonto, Ilaria Barone, Alessandra Campanelli, Francesca Cersosimo, Elisa Setten, Stefano Gianoli, Zulkifal Malik, Giuseppe Busetto, Alex Pezzotta, Alessandra Castagna, Nicolò Martinelli, Silvia Ferretti, Federico Boschi, Adam Doherty, Maria Teresa Scupoli, Chiara Cavallini, Giorgio Malpeli, Alessia Amenta, Ludovica Sagripanti, Vincenzo Silani, Patrizia Cristofori, Eugenio Scanziani, Marco Sandri, Anna Pistocchi, Patrizia Bossolasco, Marco Endrizzi, Kristin Schubert, Guido Francesco Fumagalli, Massimo Locati, Francesco Bifari, Ilaria Decimo

Issue&Volume: 2026-01-26

Abstract: Tumor-associated macrophages (TAMs) enhance cancer progression by promoting angiogenesis, extracellular matrix remodeling, and immune suppression. Nerve infiltration also contributes to tumor growth. However, the role of TAMs in promoting intratumoral nerve growth remains unclear. In this study, we have shown that TAMs express a distinct neural growth gene signature. TAMs actively enhanced neural growth within tumors and directly promoted in vitro neurite outgrowth. We identified secreted phosphoprotein 1 (SPP1) as a required mediator of TAM-driven neural growth and mTORC2 activation. Leveraging this TAM-neural growth function, we explored TAM neuroregenerative potential. Adoptive transfer of TAMs in severe complete-compressive-contusive spinal cord injury (scSCI) increased neuronal survival, axonal regrowth, and motor function recovery. Moreover, TAMs healed scSCI microenvironment and remodeled the cyst. Functional and proteomic analyses confirmed SPP1 and neural Rictor as necessary molecular mediators for TAM-induced regeneration. Our data unveil a role for TAMs in tumor innervation and neural tissue repair.

DOI: 10.1016/j.immuni.2025.12.016

Source: https://www.cell.com/immunity/abstract/S1074-7613(25)00572-2