雌激素调节的肾祖细胞决定妊娠适应和子痫前期，这一成果由
全球肾脏疾病负担表现出明显的性别二态性。谱系追踪和单细胞RNA测序显示，从青春期开始，雌性小鼠的雌激素信号支持肾脏祖细胞的自我更新和分化，以增加滤过能力，与雄性相比，降低对肾小球损伤的敏感性。这种现象随着女性肾脏适应怀孕的负荷而加速。肾祖细胞中雌激素受体α的缺失破坏了这种适应，导致先兆子痫、胎儿生长受限，并增加了母体高血压和慢性肾脏疾病的风险。受影响母亲的后代肾脏细胞较少，导致早期高血压和更容易患肾脏疾病。这些结果强调了肾脏健康和肾脏祖细胞在妊娠和子痫前期的基本作用，以及肾脏疾病中两性二态性的决定因素。
附：英文原文
Title: Estrogen-regulated renal progenitors determine pregnancy adaptation and preeclampsia
Author: Carolina Conte, Maria Lucia Angelotti, Benedetta Mazzinghi, Maria Elena Melica, Giulia Antonelli, Giulia Carangelo, Samuela Landini, Valentina Raglianti, Fiammetta Ravaglia, Luigi Cirillo, Camilla Fantini, Tommaso Dafichi, Martin Klaus, Ersilia Lucenteforte, Alice Molli, Letizia De Chiara, Anna Julie Peired, Elena Lazzeri, Hans-Joachim Anders, Laura Lasagni, Paola Romagnani
Issue&Volume: 2025-09-04
Abstract: The global burden of kidney disease displays marked sexual dimorphism. Lineage tracing and single-cell RNA-sequencing revealed that starting from puberty, estrogen signaling in female mice supports self-renewal and differentiation of renal progenitors to increase filtration capacity, reducing sensitivity to glomerular injury compared with that of males. This phenomenon accelerated as female kidneys adapted to the workload of pregnancy. Deletion of estrogen receptor α in renal progenitors disrupted this adaptation, leading to preeclampsia, fetal growth restriction, and increased maternal risk of hypertension and chronic kidney disease. Offspring from affected mothers had fewer nephrons, resulting in early-life hypertension and greater susceptibility to kidney disease. These results highlight the fundamental role of kidney fitness and renal progenitors for pregnancy and preeclampsia and as a determinant of sexual dimorphism in kidney disease.
DOI: adp4629
Source: https://www.science.org/doi/10.1126/science.adp4629