瑞典乌普萨拉大学Svante Winberg小组宣布他们提出了应激应对方式和社交失败对斑马鱼行为和脑转录组学的影响。2025年9月22日出版的《神经科学通报》发表了这项成果。

该课题组建立了一个社会失败压力模型来评估野生斑马鱼的应对能力。行为测试应用于评估参数，如大胆/探索，侵略性和位移行为。通过RNA测序评估大脑中基因表达的变化。主要结果显示害羞和大胆表型对行为和脑转录组有很强的影响。害羞系的鱼表现出显著的行为差异，而差异表达基因的数量仍然很低。相比之下，粗体线的鱼对行为的影响很小，大脑基因表达的变化明显。这项研究强调了大胆表型的重要性及其在行为和转录组水平上对社会挑战反应的影响。

据悉，与压力应对方式相对应的不同人格特征的个体在行为和神经可塑性方面存在差异。

附：英文原文

Title: Effects of Stress Coping Styles and Social Defeat on Zebrafish Behaviour and Brain Transcriptomics

Author: Huben, Pavla, Benrejdal, Lisa, Brodin, David, Axling, Johanna, Sarma, Oly Sen, Bergman, Peter, Winberg, Svante

Issue&Volume: 2025-09-22

Abstract: Individuals with divergent personality traits corresponding to stress coping styles have been suggested to differ in behavioural and neural plasticity. We used a model of social defeat stress to assess the coping ability of wild zebrafish selectively bred for boldness/shyness. Behavioural tests were applied to assess parameters such as boldness/exploration, aggressiveness, and displacement behaviour. Gene expression changes in the brain were assessed via RNA sequencing. The main results show a strong effect of shyness and boldness phenotype on behaviour and the brain transcriptome. Fish of the shy line displayed significant behavioural differences, while the number of differentially-expressed genes remained low. In contrast, fish of the bold line exhibited a small effect on behaviour and pronounced changes in brain gene expression. This study highlights the importance of boldness phenotype and its influence on the response to social challenges at the behavioural and transcriptomic levels.

DOI: 10.1007/s12264-025-01506-0

Source: https://link.springer.com/article/10.1007/s12264-025-01506-0