浙江中医药大学陈忠团队的一项最新研究提出了自下而上的中隔抑制回路介导对饮酒的预期控制。相关论文发表在2025年9月22日出版的《自然—神经科学》杂志上。

在这里，研究小组揭示了一条从内侧隔膜（MS）到SFO的抑制途径，该途径参与了小鼠预期饮酒行为的控制。MS γ-氨基丁酸（GABA）能神经元通过整合来自口腔的信号和跟踪胃肠道信号来编码水饱和信号。这些神经元接受来自臂旁核的输入，并将其传递给SFOCaMKII神经元，形成一个自下而上的通路，具有防止过度水化的活性。这种电路的破坏会导致过量的水摄入和低钠血症。他们的发现揭示了一个整合多层系统前信号来微调饮酒行为的间隔通路。

据介绍，饮酒行为不仅受到体内平衡调节，而且在血液渗透压发生任何变化之前迅速调整，称为预期口渴。稳态和预期信号在皮层下器官（SFO）汇聚；然而，在血液成分发生变化之前，向SFO传递外周信息的神经通路尚不完全清楚。

附：英文原文

Title: A bottom-up septal inhibitory circuit mediates anticipatory control of drinking

Author: Xu, Lingyu, Sun, Yuhao, Huang, Chenyuan, Zheng, Yanrong, Chen, Jialu, Ma, Xiaolong, Shi, Qiujie, Liu, Mengting, Qiu, Xiaoyun, Zhao, Qikun, Gao, Chenshu, Liao, Jie, Wang, Yi, Chen, Zhong

Issue&Volume: 2025-09-22

Abstract: Drinking behavior is not only homeostatically regulated but also rapidly adjusted before any changes in blood osmolality occur, known as anticipatory thirst satiation. Homeostatic and anticipatory signals converge in the subfornical organ (SFO); however, the neural pathways conveying peripheral information to the SFO before changes in blood composition are incompletely understood. Here we reveal an inhibitory pathway from the medial septum (MS) to the SFO that is involved in the control of anticipatory drinking behavior in mice. MS γ-aminobutyric acid (GABA)ergic neurons encode water-satiation signals by integrating cues from the oral cavity and tracking gastrointestinal signals. These neurons receive inputs from the parabrachial nucleus and relay to SFOCaMKII neurons, forming a bottom-up pathway with activity that prevents overhydration. Disruption of this circuit leads to excessive water intake and hyponatremia. Our findings reveal a septal pathway that integrates multiple layers of presystemic signals to fine-tune drinking behavior.

DOI: 10.1038/s41593-025-02056-4

Source: https://www.nature.com/articles/s41593-025-02056-4