近日，浙江大学陆展团队研究了铁催化α-取代乙烯基硅烷的对映选择性氢硅烷化反应。2025年9月18日出版的《中国化学》杂志发表了这项成果。

研究组首次报道了铁催化α-取代乙烯基硅烷的不对称硅氢化反应。该反应具有较高的区域选择性和对映体选择性，为获得对映体富集的手性邻双（硅烷）衍生Si-H键提供了有效途径。重要的是，新设计的配体中的局部立体体积效应显著提高了产率和对映体选择性。此外，还可以顺利地进行克级合成。研究组还证明了所得到的手性邻苯二甲酸双（硅烷）的衍生化，得到了高价值的环硅氧烷和硅氧烷。

附：英文原文

Title: Iron-Catalyzed Enantioselective Hydrosilylation of α-Substituted Vinylsilanes†

Author: Lingtao Wang, Minghua Li, Huachen Yan, Zhaoyang Cheng, Zhan Lu

Issue&Volume: 2025-09-18

Abstract: The first iron-catalyzed asymmetric hydrosilylation of α-substituted vinylsilanes is reported. This reaction proceeds with high regio- and enantioselectivity, providing an efficient access to enantioenriched chiral vicinal bis(silane)s bearing derivatizable Si–H bonds. Importantly, the localized steric bulky effect in the new designed ligand significantly enhances both yield and enantioselectivity. Furthermore, gram-scale synthesis could be performed smoothly. The derivatizations of the resulting chiral vicinal bis(silane)s are also demonstrated, furnishing high-value cyclosiloxane and siloxane.

DOI: 10.1002/cjoc.70268

Source: https://onlinelibrary.wiley.com/doi/10.1002/cjoc.70268