研究人员对全球分布的73个地点的1206个基因组进行了测序。在西非萨赫勒地区进化出对人类的偏好后，入侵亚种伊蚊。埃及伊蚊（Aaa）在大西洋奴隶贸易时代之后出现在美洲，并向全球扩张。最近Aaa级移民返回非洲，在最近爆发登革热的地区引入了杀虫剂耐药性和亲人类行为，这引起了人们对Aaa级移民可能增加非洲城市虫媒病毒风险的担忧。这些数据强调了抗击登革热、寨卡病毒和基孔肯雅热的复杂性，并为进一步研究这一重要的蚊子媒介提供了一个平台。
据介绍，埃及伊蚊的出现和全球扩张使一半以上的人类面临感染虫媒病毒的风险，但这种蚊子的起源以及当代基因流对虫媒病毒控制的影响尚不清楚。
附：英文原文
Title: 1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk
Author: Jacob E. Crawford, Dario Balcazar, Seth Redmond, Noah H. Rose, Henry A. Youd, Eric R. Lucas, Rusdiyah Sudirman Made Ali, Ashwaq Alnazawi, Athanase Badolo, Chun-Hong Chen, Luciano V. Cosme, Jennifer A. Henke, Kim Y. Hung, Susanne Kluh, Wei-Liang Liu, Kevin Maringer, Ademir Martins, María Victoria Micieli, Evlyn Pless, Aboubacar Sombié, Sinnathamby N. Surendran, Isra Wahid, Peter A. Armbruster, David Weetman, Carolyn S. McBride, Andrea Gloria-Soria, Jeffrey R. Powell, Bradley J. White
Issue&Volume: 2025-09-18
Abstract: The emergence and global expansion of Aedes aegypti puts more than half of all humans at risk of arbovirus infection, but the origin of this mosquito and the impact of contemporary gene flow on arbovirus control are unclear. We sequenced 1206 genomes from 73 globally distributed locations. After evolving a preference for humans in Sahelian West Africa, the invasive subspecies Ae. aegypti aegypti (Aaa) emerged in the Americas after the Atlantic slave trade era and expanded globally. Recent back-to-Africa Aaa migration introduced insecticide resistance and anthropophily into regions with recent dengue outbreaks, raising concern that Aaa movement could increase arbovirus risk in urban Africa. These data underscore developing complexity in the fight against dengue, Zika, and chikungunya and provide a platform to further study this important mosquito vector.
DOI: ads3732
Source: https://www.science.org/doi/10.1126/science.ads3732