瑞士联邦理工学院Gregoire Courtine研究小组近日取得一项新成果。经过不懈努力，他们开发出自主神经反射障碍的神经元结构。该研究于2025年9月17日发表于国际一流学术期刊《自然》杂志上。

在这里，该团队揭示了脊髓损伤和自主神经反射障碍后发展的神经元结构。同时，研究小组发现脊髓硬膜外电刺激激活了一种相互竞争但重叠的神经元结构，可以安全地调节脊髓损伤后的血压。这些对抗性神经元结构汇聚到单个神经元亚群的发现，为设计一种基于机制的干预措施提供了蓝图，该干预措施可以逆转小鼠、大鼠和SCI患者的自主神经反射障碍。这些结果为关键装置临床试验开辟了一条道路，该试验将确定硬膜外电刺激有效治疗脊髓损伤患者自主神经反射障碍的安全性和有效性。

据了解，自主神经反射障碍是一种危及生命的疾病，其特征是在脊髓损伤（SCI）后对感觉刺激的反应中发生不受控制的高血压发作。对自主神经反射障碍机制的不完整理解阻碍了治疗策略的发展，使脊髓损伤患者每天面临心脏病发作和中风的风险。

附：英文原文

Title: A neuronal architecture underlying autonomic dysreflexia

Author: Soriano, Jan Elaine, Hudelle, Remi, Mahe, Lois, Gautier, Matthieu, Teo, Alan Yue Yang, Skinnider, Michael A., Laskaratos, Achilleas, Ceto, Steven, Kathe, Claudia, Hutson, Thomas, Charbonneau, Rebecca, Girgis, Fady, Casha, Steve, Rimok, Julien, Tso, Marcus, Larkin-Kaiser, Kelly, Hankov, Nicolas, Gandhi, Aasta, Amir, Suje, Kang, Xiaoyang, Vyza, Yashwanth, Martin-Moraud, Eduardo, Lacour, Stephanie, Demesmaeker, Robin, Asboth, Leonie, Barraud, Quentin, Anderson, Mark A., Bloch, Jocelyne, Squair, Jordan W., Phillips, Aaron A., Courtine, Gregoire

Issue&Volume: 2025-09-17

Abstract: Autonomic dysreflexia is a life-threatening medical condition characterized by episodes of uncontrolled hypertension that occur in response to sensory stimuli after spinal cord injury (SCI)1. The fragmented understanding of the mechanisms underlying autonomic dysreflexia hampers the development of therapeutic strategies to manage this condition, leaving people with SCI at daily risk of heart attack and stroke2,3,4,5. Here we expose the neuronal architecture that develops after SCI and causes autonomic dysreflexia. In parallel, we uncover a competing, yet overlapping neuronal architecture activated by epidural electrical stimulation of the spinal cord that safely regulates blood pressure after SCI. The discovery that these adversarial neuronal architectures converge onto a single neuronal subpopulation provided a blueprint for the design of a mechanism-based intervention that reversed autonomic dysreflexia in mice, rats and humans with SCI. These results establish a path towards essential pivotal device clinical trials that will establish the safety and efficacy of epidural electrical stimulation for the effective treatment of autonomic dysreflexia in people with SCI.

DOI: 10.1038/s41586-025-09487-w

Source: https://www.nature.com/articles/s41586-025-09487-w