近日，北京化工大学曹达鹏团队实现了噻唑-2-乙醛基共价有机框架。2025年9月16日出版的《德国应用化学》杂志发表了这项成果。

研究组首次采用简便、高产率的方法合成了一种新型的醛取代苯并[1,2-d:4,5-d'；]双（噻唑）单体（BBTC），并首次将其作为合成亚胺连接COFs的基础材料。通过主题键转化策略，研究祖进一步合成了咪唑N杂环碳烯前体COF（BBTC-INP COF）和咪唑-2-硫酮COF（BBTC-IT COF）。有趣的是，与母体BBTC COF相比，BBTC-INP和BBTC-IT COF的光致发光量子产率分别提高了2620倍和1810倍。

这种联动变换不仅优化了光学性能，而且使Hg²⁺通过战略性地结合硫酮（C = S）基团作为特定的结合位点进行检测。特别是，BBTC-IT COF对有毒的Hg²⁺检测限达到60 nM，突出了合成的BBTC-IT COFs在荧光传感应用中的优势。总之，该工作报道了一系列新型的噻唑-2-乙醛基COFs，这在很大程度上丰富了COFs的多样性，也将刺激更多基于BBTC的COFs的合成，用于不同的应用。

附：英文原文

Title: Thiazole-2-Carbaldehyde-Based Covalent Organic Frameworks

Author: Xuefeng Wang, Jing Ning, Jianping Zhang, Lingyu Ge, Hongtao Wei, Shitao Wang, Long Hao, Dapeng Cao

Issue&Volume: 2025-09-16

Abstract: We first synthesize a novel aldehyde-substituted benzo[1,2-d:4,5-d']bis(thiazole) monomer (BBTC) via a facile method with a high yield, and the BBTC is used for the first time as a building block for synthesis of imine-linked COFs. By using linkage transformation strategy, we further synthesize an imidazole N-heterocyclic carbene precursor COF (BBTC-INP COF) and the imidazole-2-thione COF (BBTC-IT COF). Interestingly, the BBTC-INP and BBTC-IT COFs exhibit 2620- and 1810-fold enhancements in photoluminescence quantum yields, respectively, compared to the parent BBTC COF. This linkage transformation not only optimizes the optical performance but also enables effective Hg2 detection through the strategic incorporation of thione (C═S) groups as specific binding sites. In particular, the BBTC-IT COF presents outstanding selectivity and sensitivity for toxic Hg2 detection, and the limit of detection reaches 60 nM, highlighting the advantage of as-synthesized BBTC-IT COFs in fluorescence sensing applications. In short, this work reports a series of novel thiazole-2-carbaldehyde-based COFs, which largely enriches the diversity of COFs and would also stimulate the synthesis of more BBTC-based COFs for different applications.

DOI: 10.1002/anie.202516013

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202516013