西班牙研究理事会(CSIC) -马德里自治大学María Llorens-Martín小组宣布他们探明了成人海马神经发生受神经精神疾病、人口统计学和生活方式相关因素的影响。相关论文发表在2025年9月15日出版的《细胞—干细胞》杂志上。

该课题组人员试图确定重度抑郁症、精神分裂症和双相情感障碍是否会威胁人类AHN的完整性和齿状回（DG）神经源性生态位（新神经元生长的特殊微环境）的内稳态。他们的研究结果表明，AHN的初始和中期阶段以及生态位的不同组成部分在这些疾病中受到选择性影响。不仅在患有这些疾病的患者中，而且在神经健康对照个体中，人口统计学和各种与生活方式相关的因素（如酒精和滥用药物的消费）调节AHN和构成生态位的细胞。这些数据可能与设计未来治疗和预防心理健康状况的策略有关。

据介绍，成人海马神经发生（AHN）调节海马依赖功能，是生理衰老和神经退行性疾病的目标。神经精神障碍患者表现出海马异常，这可能与AHN的改变有关。

附：英文原文

Title: Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors

Author: Berenice Márquez-Valadez, Marta Gallardo-Caballero, María Llorens-Martín

Issue&Volume: 2025-09-15

Abstract: Adult hippocampal neurogenesis (AHN) regulates hippocampal-dependent functions and is targeted by physiological aging and neurodegenerative conditions. Patients with neuropsychiatric disorders show hippocampal abnormalities that might be related to changes in AHN. Here, we sought to determine whether major depression, schizophrenia, and bipolar disorder threaten the integrity of human AHN and the homeostasis of the dentate gyrus (DG) neurogenic niche—a specialized microenvironment in which new neurons grow. Our results show that the initial and intermediate stages of AHN, as well as distinct components of the niche, are selectively affected in these disorders. Demographics and various lifestyle-related factors (such as the consumption of alcohol and drugs of abuse) modulate both AHN and the cells that compose the niche, not only in patients with these disorders but also in neurologically healthy control individuals. These data might be relevant for the design of future strategies to treat and prevent mental health conditions.

DOI: 10.1016/j.stem.2025.08.010

Source: https://www.cell.com/cell-stem-cell/abstract/S1934-5909(25)00302-9