哥伦比亚大学Charles S. Zuker研究团队报道了一个控制圆满反应的大脑中心。相关论文于2025年9月10日发表于国际顶尖学术期刊《细胞》杂志上。

该研究组剖析了驱动对甜味反应的回路，发现对甜味敏感的杏仁核神经元与纹状终核（BNST）的床核相连，以促进甜味诱发的消费。接下来，课题组人员证明了BNST作为一个中心枢纽，将食欲信号转化为消费，并将感官输入与内部状态联系起来，不仅是对甜味，还有对其他刺激（如盐或食物），以灵活地调节圆满行为。利用单细胞功能成像，该课题组发现BNST编码的集合活动刺激身份和动物的内部状态。最后，该研究团队证明操纵BNST活动可以双向改变完成性反应。总之，这些发现阐明了内部状态是如何调节感觉反应的，描述了一般大脑消耗的特征，并为GLP1R激动剂的作用部位和帮助促进病理状态下体重增加的策略提供了新的见解。

据介绍，对甜味的天生吸引力介导了食欲和圆满反应。

附：英文原文

Title: A brain center that controls consummatory responses

Author: Jose A. Canovas, Li Wang, Ahmed A.M. Mohamed, Larry F. Abbott, Charles S. Zuker

Issue&Volume: 2025-09-10

Abstract: The innate attraction to sweet mediates appetitive and consummatory responses. Here, we dissected the circuit driving responses to sweet and showed that amygdala neurons tuned to sweet connect to the bed nucleus of the stria-terminalis (BNST) to promote sweet-evoked consumption. Next, we demonstrate that the BNST functions as a central hub, transforming appetitive signals into consumption and linking sensory inputs to the internal state, not only for sweet but also for other stimuli such as salt or food, to flexibly regulate consummatory behaviors. Using single-cell functional imaging, we show that ensemble activity in the BNST encodes stimulus identity and the animal’s internal state. Finally, we demonstrate that manipulating BNST activity can bidirectionally transform consummatory responses. Together, these findings illustrate how the internal state modulates sensory responses, characterize a general brain dial for consumption, and provide fresh insights into sites of action of GLP1R agonists and a strategy to help promote weight gain in pathological states.

DOI: 10.1016/j.cell.2025.08.021

Source: https://www.cell.com/cell/abstract/S0092-8674(25)00976-6