超加工食品消费对男性生殖和代谢健康的影响，这一成果由哥本哈根大学Romain Barrès团队经过不懈努力而取得。这一研究成果于2025年8月28日发表在国际顶尖学术期刊《细胞—代谢》上。

课题组研究人员进行了一项营养试验（NCT05368194），采用对照、2 × 2交叉设计，测试了超加工食品是否会损害生殖和代谢健康，并因过量热量摄入而进一步恶化。比较未加工饮食和超加工饮食的反应，发现体重和低密度脂蛋白（LDL）：高密度脂蛋白（HDL）比率增加，与热量负荷无关。参与能量代谢和精子发生的几种激素受到影响，包括生长/分化因子15和促卵泡激素水平下降。精子质量趋向于受损，总活力下降。在不一致的饮食中检测到污染物积累的差异，例如，在超加工饮食之后，血浆锂减少，血清中邻苯二甲酸单（4-甲基-7-羧基庚基）邻苯二甲酸酯（cxMINP）水平有增加的趋势。单独改变热量负荷对测量结果有明显的影响。这项研究提供的证据表明，无论摄入过多的热量，食用超加工食品对心脏代谢和生殖结果都是有害的。

据介绍，食用超加工食品与热量摄入增加和健康受损有关。

附：英文原文

Title: Effect of ultra-processed food consumption on male reproductive and metabolic health

Author: Jessica M. Preston, Jo Iversen, Antonia Hufnagel, Line Hjort, Jodie Taylor, Clara Sanchez, Victoria George, Ann N. Hansen, Lars ngquist, Susan Hermann, Jeffrey M. Craig, Signe Torekov, Christian Lindh, Karin S. Hougaard, Marcelo A. Nóbrega, Stephen J. Simpson, Romain Barrès

Issue&Volume: 2025-08-28

Abstract: Consumption of ultra-processed food is associated with increased caloric intake and impaired health. Here, we conducted a nutrition trial (NCT05368194) with controlled, 2 × 2 crossover design and tested whether ultra-processed food impairs reproductive and metabolic fitness, with further aggravation by excess caloric intake. Comparing the response from an unprocessed to ultra-processed diet identified increased body weight and low-density lipoprotein (LDL):high-density lipoprotein (HDL) ratio, independent of caloric load. Several hormones involved in energy metabolism and spermatogenesis were affected, including decreased levels of growth/differentiation factor 15 and follicle-stimulating hormone. Sperm quality trended toward impairment, with a decrease in total motility. Differential accumulation of pollutants between the discordant diets were detected, such as decreased plasma lithium and a trend for increased levels of the phthalate mono(4-methyl-7-carboxyheptyl)phthalate (cxMINP) in serum, following the ultra-processed diet. Alteration in caloric load alone had distinct effects on the measured outcomes. This study provides evidence that consumption of ultra-processed food is detrimental for cardiometabolic and reproductive outcomes, regardless of excessive caloric intake.

DOI: 10.1016/j.cmet.2025.08.004

Source: https://www.cell.com/cell-metabolism/abstract/S1550-4131(25)00360-2