2025年8月21日出版的《细胞》杂志发表了科学家的一项最新研究成果。来自德国
研究小组发现AntiSYS是番茄细胞因子系统素的天然抑制剂。AntiSYS是一种系统蛋白样肽，编码在一个基因序列中，有另外的类似物，其中三个包含新发现的激动系统蛋白。AntiSYS是一种有效的系统素受体特异性拮抗剂。缺乏AntiSYS的番茄突变体表现出生长异常和生殖适应性降低。在缺乏功能性系统素受体的植物中没有观察到这些AntiSYS缺乏症的症状，这表明AntiSYS在平衡拮抗系统素方面的作用。与动物体内控制免疫稳态的拮抗白介素类似，AntiSYS在番茄植物细胞因子活性的调控中起着至关重要的作用。
据介绍，严格调控免疫激活对植物健康至关重要。植物如何控制其免疫刺激植物细胞因子的作用在很大程度上是未知的。
附：英文原文
Title: A receptor antagonist counterbalances multiple systemin phytocytokines in tomato
Author: Lei Wang, Louis-Philippe Maier, Nga Pham, Yan L. Wang, Xu Wang, Andreas Schaller, Judith Fliegmann, Matthias Erb, Thomas Boller, Georg Felix
Issue&Volume: 2025-08-21
Abstract: Tight regulation of immune activation is crucial for plant health. How plants control the actions of their immunostimulatory phytocytokines is largely unknown. Here, we identify antiSYS as a natural inhibitor of the tomato cytokine systemin. AntiSYS is a systemin-like peptide encoded in a gene cluster with four additional paralogs, three of which comprise newly identified agonistic systemins. AntiSYS is a potent and specific antagonist of the systemin receptor. Tomato mutants lacking antiSYS show aberrant growth and reduced reproductive fitness. These symptoms of antiSYS deficiency are not observed in plants lacking functional systemin receptors, suggesting a role of antiSYS in counterbalancing agonistic systemins. Thus, reminiscent of antagonistic interleukins controlling immune homeostasis in animals, antiSYS serves a crucial role in the regulation of phytocytokine activity in tomato plants.
DOI: 10.1016/j.cell.2025.07.044
Source: https://www.cell.com/cell/abstract/S0092-8674(25)00866-9