课题组发现，在出生第一周摄入母体免疫球蛋白G (IgG)，在断奶后几周抑制微生物依赖的适应性免疫反应。这种活性与母体抗体有关，母体抗体可以结合新生儿肠道中的细菌，微生物- IgG复合物能够参与后代的Fc和补体依赖性效应功能。摄入微生物群特异性母体IgG也限制了新生儿对断奶时遇到的膳食抗原的异常反应。这些发现表明，在发育过程中，面对食物和细菌抗原的动态变化，母体IgG在出生后早期参与后代的免疫系统，以调节粘膜反应并加强肠道内稳态。
据悉，母体抗体从根本上调节发育中的婴儿的肠道免疫，但这一过程的机制仍不清楚。
附：英文原文
Title: Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens
Author: Meera K. Shenoy, Diane M. Rico, Alina K. Lorant, Hamadoun Touré, Shannon Gordon, Luke J. Milburn, Jeanette S. Schwensen, Madelyn E. Cabán, Meghan A. Koch
Issue&Volume: 2025-08-14
Abstract: Maternal antibodies fundamentally regulate gut immunity in the developing infant, yet the mechanisms underlying this process remain elusive. We found that maternal immunoglobulin G (IgG), ingested in the first week of life, restrained microbiota-dependent adaptive immune responses weeks later, after weaning. This activity was linked to maternal antibodies that could bind bacteria in the neonatal gut and the ability of microbe-IgG complexes to engage Fc and complement-dependent effector functions in offspring. Ingestion of microbiota-specific maternal IgG also limited aberrant neonatal responses to dietary antigens encountered at weaning. These discoveries suggest that maternal IgG engages the immune system of offspring in early postnatal life to tune mucosal responses and reinforce intestinal homeostasis in the face of dynamic shifts in food and bacterial antigens during development.
DOI: ado5294
Source: https://www.science.org/doi/10.1126/science.ado5294