免疫学研究所Tobias Bopp研究团队在研究中取得进展。他们的论文报道了多胺通过调节性T细胞的功能特化调节适应性抗肿瘤免疫。相关论文于2025年7月31日发表于国际顶尖学术期刊《免疫学》杂志上。

研究人员报道了肿瘤微环境中多胺的过度释放导致T_reg细胞的功能极化以蛋白激酶CK2 （CK2）依赖的方式向免疫抑制方向发展。多胺剥夺以及遗传或药理学抑制T_reg细胞中CK2活性诱导T_reg细胞的组织修复特性，从而协调有效的抗肿瘤2型免疫反应和协调组织修复机制，以支持肿瘤根除。这些发现表明，T_reg细胞功能的靶向调节可以作为癌症治疗的潜在途径。

据介绍，在癌症中，代谢变化和不受控制的肿瘤生长改变了营养可利用性，影响抗肿瘤免疫反应。调节性T细胞（T_reg）是T细胞的一个亚群，具有免疫抑制特性，也可以影响组织稳态和修复。然而，目前尚不清楚这些功能是如何受到分子控制的，以及它们是否受到肿瘤代谢的影响。

附：英文原文

Title: Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

Author: Georg Bündgen, Alexander Ulges, Jan Pietruschka, Natalia Truong-Andrievici, Matthias Klein, Karolina Romaniuk, Fabian Schmitt, Mathias Hagen, Joachim G. Seebass, Lenart Zezlina, Lara Stein, Hans Christian Probst, Ute Distler, Stefan Tenzer, Michael Lohoff, Addi J. Romero-Olmedo, Henrik Mei, Toszka Bohn, Michael Delacher, Thierry Schmidlin, Matthias M. Gaida, Ivan Dikic, Charles Imbusch, Hansjrg Schild, Tobias Bopp

Issue&Volume: 2025-07-31

Abstract: In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that can also influence tissue homeostasis and repair. However, it is not known how these functions are molecularly controlled and whether they are influenced by tumor metabolism. Here, we report that excessive release of polyamines in the tumor microenvironment directs the functional polarization of Treg cells toward immunosuppression in a protein kinase CK2 (CK2)-dependent manner. Polyamine deprivation as well as genetic or pharmacological inhibition of CK2 activity in Treg cells induced tissue reparative properties in Treg cells that orchestrated efficient antitumor type 2 immune responses and coordinated tissue repair mechanisms to support tumor eradication. These findings suggest that targeted modulation of Treg cell functions could be leveraged as a potential avenue for cancer therapy.

DOI: 10.1016/j.immuni.2025.07.007

Source: https://www.cell.com/immunity/abstract/S1074-7613(25)00316-4