该研究组发现，母核海马腹侧CA1区（vCA1）的神经元通过速率和基于theta的时间编码来编码熟悉的同类的身份和社会属性，特别是性别和张力。社会记忆的光遗传再激活诱导了女性的位置偏好，而不是男性。海马上游背侧CA2区或内侧杏仁核的消融破坏了性别表征和社会记忆效价的性别二分法。vCA1神经元主题的双重编码方案，以表示身份和社会属性熟悉的同一性作为一个内聚记忆。
研究人员表示，识别熟悉的个体对于动物之间的适应性社会互动至关重要。然而，包含性信息的社会记忆的多维性仍未得到阐明。
附：英文原文
Title: Representation of sex-specific social memory in ventral CA1 neurons
Author: Akiyuki Watarai, Kentaro Tao, Teruhiro Okuyama
Issue&Volume: 2025-07-03
Abstract: Recognizing familiar individuals is crucial for adaptive social interactions among animals. However, the multidimensional nature of social memory encompassing sexual information remains unelucidated. We found that neurons in the ventral CA1 region (vCA1) of the mouse hippocampus encoded the identities and social properties, specifically sex and strain, of familiar conspecifics by using both rate and theta-based temporal coding. Optogenetic reactivation of social memories of females, but not males, induced place preference. Ablation of the upstream hippocampal dorsal CA2 region or the medial amygdala disrupted the representation of sex and the sexual dichotomy of social memory valence. Thus, vCA1 neurons use dual coding schemes to represent the identities and social properties of familiar conspecifics as a cohesive memory.
DOI: adp3814
Source: https://www.science.org/doi/10.1126/science.adp3814