直接电刺激引起视觉感觉的电生理特征，这一成果由中国科学院大学王亮研究组经过不懈努力而取得。2025年7月23日出版的《神经科学通报》发表了这项成果。

为了解决这个问题，该课题组研究人员招募了69名患者，他们在有创性电刺激期间经历了视觉感受，同时记录了颅内脑电图（iEEG）数据。课题组研究人员发现，在涉及不同大脑网络的分布区域，功率谱斜率明显变平，与非感觉条件相比，在引发视觉感觉时，综合信息减少。基于最小信息分区的进一步分析表明，重新配置的网络相互作用主要涉及额叶下皮层、后颞上沟和颞顶叶交界处。额下回平坦化的功率谱斜率也与综合信息相关。综上所述，这项研究表明，改变的电生理特征提供了对主观视觉感觉背后的神经机制的见解。

据悉，直接电刺激人体皮层可以产生主观的视觉感觉，但这些感觉是不稳定的。潜在的机制可能源于受刺激部位外分布网络内电生理活动的差异。

附：英文原文

Title: Electrophysiological Signatures of Visual Sensations Elicited by Direct Electrical Stimulation

Author: Li, Yan-Yan, Zhang, Bo, Wang, Jing, Saalmann, Yuri B., Afrasiabi, Mohsen, Lv, Peng-Cheng, Wang, Hai-Xiang, Xiang, Huan-Huan, Wang, Meng-Yang, Luan, Guo-Ming, Knight, Robert T., Wang, Liang

Issue&Volume: 2025-07-23

Abstract: Direct electrical stimulation of the human cortex can produce subjective visual sensations, yet these sensations are unstable. The underlying mechanisms may stem from differences in electrophysiological activity within the distributed network outside the stimulated site. To address this problem, we recruited 69 patients who experienced visual sensations during invasive electrical stimulation while intracranial electroencephalography (iEEG) data were recorded. We found significantly flattened power spectral slopes in distributed regions involving different brain networks and decreased integrated information during elicited visual sensations compared with the non-sensation condition. Further analysis based on minimum information partitions revealed that the reconfigured network interactions primarily involved the inferior frontal cortex, posterior superior temporal sulcus, and temporoparietal junction. The flattened power spectral slope in the inferior frontal gyrus was also correlated with integrated information. Taken together, this study indicates that the altered electrophysiological signatures provide insights into the neural mechanisms underlying subjective visual sensations.

DOI: 10.1007/s12264-025-01464-7

Source: https://link.springer.com/article/10.1007/s12264-025-01464-7