荷兰内梅亨大学Benno Roozendaal团队的最新研究揭示了基底外侧杏仁核的去肾上腺素能激活促进了对时间相近的类似事件的记忆特异性。该项研究成果发表在2025年7月23日出版的《自然—神经科学》上。

然而，在他们的生活中，该研究团队经常会遇到类似的事件，这些事件可能会导致不正确的联想在情感上得到加强。

在这里，研究组提供了证据，在大鼠中，BLA的去甲肾上腺素能激活通过海马齿状回内miR-134调节的巩固过程，促进了时间相近的类似事件的离散记忆的形成。海马区miR-134的靶向下调足以诱导记忆特异性，而不影响记忆的强度。值得注意的是，BLA的去甲肾上腺素能激活并没有招募海马miR-134介导的机制来增强单一事件的记忆。这些发现表明，在“需要”的基础上，BLA采用了一种质量不同的神经机制来促进相似记忆表征的分离，从而能够选择性地加强正确关联到长期记忆中。

据介绍，基底外侧杏仁核（BLA）的去肾上腺素能激活促进了对情绪兴奋经历的强烈和持久的记忆。

附：英文原文

Title: Noradrenergic activation of the basolateral amygdala facilitates memory specificity for similar events experienced close in time

Author: Atucha, Erika, Pais, Mariana, Ronzoni, Giacomo, Schoenmaker, Chantal, Atsak, Piray, Roura, David, Lohkamp, Klara J., Schelling, Gustav, McGaugh, James L., Glennon, Jeffrey C., Aschrafi, Armaz, Roozendaal, Benno

Issue&Volume: 2025-07-23

Abstract: Noradrenergic activation of the basolateral amygdala (BLA) promotes strong and lasting memories of emotionally arousing experiences. However, in our lives, we often encounter similar events that may be confused and result in emotional strengthening of incorrect associations. Here we provide evidence, in rats, that noradrenergic activation of the BLA promotes the formation of discrete memories of similar events that were experienced close in time, via a miR-134-regulated consolidation process within the dentate gyrus of the hippocampus. Targeted downregulation of miR-134 in the hippocampus was sufficient to induce memory specificity, without affecting the strength of the memory. Notably, noradrenergic activation of the BLA did not recruit this hippocampal miR-134-mediated mechanism in enhancing memory of a single event. These findings indicate that the BLA engages a qualitatively different neural mechanism on an ‘as-needed’ basis to facilitate the separation of similar memory representations, enabling the selective strengthening of correct associations into long-term memory.

DOI: 10.1038/s41593-025-02014-0

Source: https://www.nature.com/articles/s41593-025-02014-0