中国科学技术大学周逸峰团队取得一项新突破。他们开发出丘脑网状核中的细小白蛋白和生长抑素神经元调节小鼠V1视觉信息加工。相关论文于2025年7月21日发表在《神经科学通报》杂志上。

研究小组证明，TRN中表达生长抑素（SOM）和小白蛋白（PV）的神经元投射到背侧展状核，并调节初级视觉皮层（V1）的定向选择和视觉信息处理能力。这些发现表明，TRN中的SOM阳性和PV阳性神经元是V1视觉信息编码的强大调节剂，揭示了该丘脑核核在影响视觉加工中的新作用。

据悉，大量研究证明，丘脑网状核（TRN）在调节感觉编码中起着至关重要的作用，甚至在视觉加工的早期阶段。定向选择是一种重要的神经反应，是通过边缘感知来检测物体的关键。

附：英文原文

Title: Parvalbumin and Somatostatin Neurons in the Thalamic Reticular Nucleus Modulate Visual Information Processing in V1 of Mouse

Author: Bu, Jiamin, Xu, Guangwei, Zhou, Yifeng

Issue&Volume: 2025-07-21

Abstract: The thalamic reticular nucleus (TRN) plays a crucial role in regulating sensory encoding, even at the earliest stages of visual processing, as evidenced by numerous studies. Orientation selectivity, a vital neural response, is essential for detecting objects through edge perception. Here, we demonstrate that somatostatin (SOM)-expressing and parvalbumin (PV)-expressing neurons in the TRN project to the dorsal lateral geniculate nucleus and modulate orientation selectivity and the capacity for visual information processing in the primary visual cortex (V1). These findings show that SOM-positive and PV-positive neurons in the TRN are powerful modulators of visual information encoding in V1, revealing a novel role for this thalamic nucleus in influencing visual processing.

DOI: 10.1007/s12264-025-01458-5

Source: https://link.springer.com/article/10.1007/s12264-025-01458-5