中南大学温猛研究团队在研究中取得进展。他们报道了连接免疫与代谢调控的cGAS。这一研究成果于2025年7月17日发表在国际顶尖学术期刊《分子细胞生物学报》上。

课题组提出一种范式转换，将cGAS定位于免疫和代谢的交叉点。该研究团队探讨了它在脂肪细胞和其他代谢组织中的多方面作用，突出了新兴的治疗机会和未来的研究方向。

据悉，最近的研究表明，环鸟苷单磷酸腺苷（AMP）合成酶（cGAS）作为细胞质DNA传感器，在先天免疫之外发挥着至关重要的作用。特别是在脂肪组织中，cGAS作为代谢哨兵，对线粒体应激做出反应，并导致炎症、胰岛素抵抗和能量失衡。这些作用通过干扰素刺激基因（STING）依赖性和非依赖性途径发生，包括自噬、染色质重塑和转录重编程。

附：英文原文

Title: cGAS: Bridging Immunity and Metabolic Regulation

Author: Wang, Jing, Meng, Wen

Issue&Volume: 2025-07-17

Abstract: Recent advances have revealed that cyclic guanosine monophosphate–adenosine monophosphate (AMP) synthase (cGAS), classically recognized as a cytosolic DNA sensor, plays crucial roles beyond innate immunity. Particularly in the adipose tissue, cGAS functions as a metabolic sentinel, responding to mitochondrial stress and contributing to inflammation, insulin resistance, and energy imbalance. These effects occur through both stimulator of interferon genes (STING)-dependent and STING-independent pathways, involving autophagy, chromatin remodeling, and transcriptional reprogramming. Here, we propose a paradigm shift positioning cGAS at the intersection of immunity and metabolism. We explore its multifaceted roles in adipocytes and other metabolic tissues, highlighting emerging therapeutic opportunities and future research directions.

DOI: 10.1093/jmcb/mjaf018

Source: https://academic.oup.com/jmcb/advance-article/doi/10.1093/jmcb/mjaf018/8205559searchresult=1