用电刺激和记录绘制人类丘脑-皮层连接图谱，这一成果由斯坦福大学医学院Josef Parvizi研究小组经过不懈努力而取得。这一研究成果发表在2025年7月15日出版的国际学术期刊《自然—神经科学》上。

在这项研究中，研究小组提供了27名人类参与者的4864个脑部位的电生理脑电连接图谱，并在皮层区域和多个丘脑核植入了重复的单脉冲电刺激和记录。课题组人员显示了由特定大脑区域的扰动引起的明显的光谱特征。已确定的脑顶连通性特征显示出高度组织化但不同的模式，表明每个特征可能对应于大脑区域之间的单独信息传输模式。值得注意的是，小组报告了一种新的波形，具有独特的时间和空间特征，与丘脑刺激特别相关，即同侧和对侧皮质区域的延迟发作θ振荡。这些发现有助于更详细地了解人类大脑的功能结构，并为开发生物学信息计算模型提供有价值的数据。

研究人员表示，大脑的功能结构是由其组成部分之间的电生理相互作用形成的，包括皮层和皮层下结构。

附：英文原文

Title: Mapping human thalamocortical connectivity with electrical stimulation and recording

Author: Lyu, Dian, Stiger, James Robert, Lusk, Zoe, Buch, Vivek, Parvizi, Josef

Issue&Volume: 2025-07-15

Abstract: The brain’s functional architecture is shaped by electrophysiological interactions between its components, encompassing both cortical and subcortical structures. In this study, we provide an atlas of electrophysiological causal connections across 4,864 brain sites in 27 human participants using repeated single-pulse electrical stimulations and recordings with intracranial electrodes implanted in cortical regions and multiple thalamic nuclei. We show distinct spectral signatures elicited by perturbations of specific brain areas. Identified features of causal connectivity exhibited highly organized yet distinct patterns, indicating that each feature may correspond to a separate mode of information transmission across brain regions. Notably, we report a new waveform with unique temporal and spatial characteristics specifically linked to thalamic stimulations, namely delayed-onset theta oscillations in both ipsilateral and contralateral cortical regions. These findings contribute to a more detailed understanding of the human brain’s functional architecture and offer valuable data for the development of biologically informed computational models.

DOI: 10.1038/s41593-025-02009-x

Source: https://www.nature.com/articles/s41593-025-02009-x