斯坦福大学医学院Josef Parvizi课题组在研究中取得进展。他们开发出人类脑岛与海马体在记忆编码过程中的直接相互作用。2025年7月14日，国际知名学术期刊《自然—神经科学》发表了这一成果。

海马体对情景记忆的编码至关重要，但在这个过程中它如何与皮层区域相互作用尚不清楚。在这项研究中，16名参与者在脑岛（217个位点）和海马体（131个位点）植入电极，观看有情感价值的词语，并试图回忆它们。在编码过程中，岛状神经元群的一个子集显示出预测成功回忆的非周期性活动的变化。这些岛屿的变化发生在海马体θ波之后，但发生在海马体波纹之前。另一部分岛状部位对单词效价有反应，与记忆表现无关。直接电刺激与记忆相关的岛状部位诱发了同侧海马的早期反应，而刺激与价相关的部位则没有。相反，刺激海马会在所有岛岛产生缓慢的、可变的信号，这表明海马和岛岛之间的交流是不对称的。这些发现提供了中尺度海马与特定皮质结构内功能选择性神经元群相互作用的一瞥。

附：英文原文

Title: Direct interactions between the human insula and hippocampus during memory encoding

Author: Huang, Weichen, Lyu, Dian, Stieger, James R., Gotlib, Ian H., Buch, Vivek, Wagner, Anthony D., Parvizi, Josef

Issue&Volume: 2025-07-14

Abstract: The hippocampus is critical for encoding episodic memories, but how it interacts with cortical regions during this process remains unclear. In this study, 16 participants with implanted electrodes in the insula (217 sites) and hippocampus (131 sites) viewed emotionally valenced words and attempted to recall them. During encoding, one subset of insular neuronal populations showed changes in aperiodic activity that predicted successful recall. These insular changes followed hippocampal theta but preceded hippocampal ripples. Another subset of insular sites responded to word valence, unrelated to memory performance. Direct electrical stimulation of memory-related insular sites evoked early responses in the ipsilateral hippocampus, whereas stimulation of valence-related sites did not. Conversely, stimulating hippocampal sites produced slow, variable signals across all insular sites, suggesting asymmetric communication between the hippocampus and the insula. These findings provide a glimpse of mesoscale hippocampal interactions with functionally selective neuronal populations within a given cortical structure.

DOI: 10.1038/s41593-025-02005-1

Source: https://www.nature.com/articles/s41593-025-02005-1