北京生命组学研究所贺福初课题组发现了即将到来的蛋白质组学驱动的精准医疗时代。相关论文于2025年7月14日发表在《国家科学评论》杂志上。

2019年强调的“蛋白质组学驱动的精准医学”概念强调了蛋白质组学通过更深入地了解动态生物过程来改变精准医学的潜力。从那时起，这一领域取得了显著的进步，与蛋白质表达谱、翻译后修饰、蛋白质-蛋白质相互作用和空间蛋白质组学等关键支柱相互联系，从而改变了医疗保健。技术进步导致了蛋白质组学综合参考图谱的创建，超过90%的人类蛋白质编码基因的鉴定，以及器官内详细的细胞和分子景观。

蛋白质组学通过开发衰老模型，以更高的蛋白质风险评分预测疾病风险，识别痴呆症等早期疾病的生物标志物，以及获得FDA批准的多种癌症生物标志物，显著推进了健康监测和疾病监测。通过深入了解蛋白质组学的复杂性和动态，蛋白质组学正在彻底改变人们对疾病的理解、诊断和治疗，并牢固地确立了其作为精准医学基石的地位。

附：英文原文

Title: The coming era of proteomics-driven precision medicine

Author: Jiang, Ying, Wang, Jian, Sun, Aihua, Zhang, Hongxing, Yu, Xiaobo, Qin, Weijie, Ying, Wantao, Li, Yanchang, Chang, Cheng, Wang, Xiaowen, Xie, Linhai, Liu, Wei, Liu, Jialin, Zhang, Xiaomei, Yan, Qunjiao, Zou, Yu, Zhao, Chuanping, Sun, Haofan, Zhang, Jian, Su, Shicheng, Gao, Qiang, He, Fuchu

Issue&Volume: 2025-07-14

Abstract: The concept of ‘Proteomics-Driven Precision Medicine’ highlighted in 2019, emphasized the potential of proteomics to transform precision medicine by offering deeper insights into dynamic biological processes. Since then, this field has seen remarkable advancements, interlinking with key pillars such as protein expression profiling, post-translational modifications, protein-protein interactions, and spatial proteomics to transform healthcare. Technological progress has led to the creation of comprehensive reference maps of proteomes, identification of over 90% of human protein-coding genes, and detailed cellular and molecular landscapes within organs. Proteomics has significantly advanced health monitoring and disease surveillance by developing aging models, predicting disease risks with superior protein risk scores, identifying biomarkers for early conditions like dementia, and securing FDA approval for multiple cancer biomarkers. By providing deeper insights into the proteome's complexity and dynamics, proteomics is revolutionizing our understanding, diagnosis, and treatment of diseases, firmly establishing itself as a cornerstone of precision medicine.

DOI: 10.1093/nsr/nwaf278

Source: https://dx.doi.org/10.1093/nsr/nwaf278