该团队提出了一种骨整合机械神经假体，它结合了改良的硬组织和软组织以及永久植入的硬件，以神经为载体的设计。课题组人员开发了神经细胞信号和关节运动之间的仿生耦合，超越了现有控制方法的多功能性，这些方法依赖于传统的截肢细胞培养和表面肌电图。他们的发现还表明，优越的残余神经细胞功能可以使假肢的运动速度超过完整的生理。解剖学上的假肢整合可能是必要的，以满足甚至可能超过完整肢体的运动能力。
研究人员表示，下肢假体通过机械重新设计而进化，优先考虑改善循环运动。然而，这种有限的肢体修复方法阻碍了恢复构成人类运动能力剩余部分的多功能无环运动的必要进展。
附：英文原文
Title: Tissue-integrated bionic knee restores versatile legged movement after amputation
Author: Tony Shu, Daniel Levine, Seong Ho Yeon, Ethan Chun, Christopher C. Shallal, John McCullough, Rickard Brnemark, Matthew J. Carty, Marco Ferrone, Sean Boerhout, Alexander Ko, Corey L. Sullivan, Gloria Zhu, Michael Nawrot, Matthew Carney, Ged Wieschhoff, Gabriel Friedman, Hugh Herr
Issue&Volume: 2025-07-10
Abstract: Lower-extremity prostheses have evolved through mechanical redesigns that prioritize improved cyclic locomotion. However, this limited approach to limb restoration has precluded necessary progress toward recovering the versatile acyclic movements that constitute the remainder of human athleticism. We present an osseointegrated mechanoneural prosthesis that incorporates modified hard and soft tissues along with permanently implanted hardware in a neuroembodied design. We developed a biomimetic coupling between neuromuscular signaling and joint movement that exceeds the versatility of established control methods, which depend upon conventional amputation musculature and surface electromyography. Our findings also reveal that superior residual neuromuscular function can enable prosthetic movement speeds surpassing that of intact physiology. Anatomical prosthetic integration may be necessary for meeting, and possibly exceeding, the movement capabilities of an intact limb.
DOI: adv3223
Source: https://www.science.org/doi/10.1126/science.adv3223