中国农业科学院谷晓峰小组在研究中取得进展。他们提出了水稻单细胞多组学图谱。2025年7月9日，国际知名学术期刊《自然》发表了这一成果。

在这里，研究小组报告了水稻的单细胞多组学图谱，水稻是世界上主要的作物之一。通过同时分析来自8个器官的116564个细胞的染色质可及性和RNA表达，该团队确定了细胞类型特异性基因调控网络，并描述了新的细胞状态，如花分生组织的“过渡状态”。基于他们的网络分析，该研究组揭示了细胞类型特异性调控枢纽RSR1、F3H和LTPL120在水稻发育过程中的功能。他们的分析揭示了细胞类型和农艺性状之间的相关性，以及进化过程中保守和分化的细胞类型功能。总之，这项研究不仅为一种主要作物提供了独特的单细胞多组学抗性，而且促进了他们对水稻细胞类型功能和潜在分子程序的理解。

研究人员表示，真核生物的细胞功能是由特定的基因表达程序驱动的，这依赖于染色质结构。

附：英文原文

Title: A single-cell multi-omics atlas of rice

Author: Wang, Xiangyu, Huang, Huanwei, Jiang, Sanjie, Kang, Jingmin, Li, Dongwei, Wang, Kailai, Xie, Shang, Tong, Cheng, Liu, Chaofan, Hu, Guihua, Li, Haoqian, Li, Cong, Yang, Liwen, Ding, Yike, Li, Shang-Tong, Wang, Faming, Lohmann, Jan U., Liang, Zhe, Gu, Xiaofeng

Issue&Volume: 2025-07-09

Abstract: Cell functions across eukaryotes are driven by specific gene expression programs, which are dependent on chromatin structure1,2,3. Here we report a single-cell multi-omics atlas of rice, one of the world’s major crops. By simultaneously profiling chromatin accessibility and RNA expression in 116,564 cells from eight organs, we identified cell-type-specific gene regulatory networks and described novel cell states, such as a ‘transitional state’ in floral meristems. On the basis of our network analyses, we uncovered the function of the cell-type-specific regulatory hubs RSR1, F3H and LTPL120 during rice development. Our analysis revealed correlations between cell type and agronomic traits, as well as conserved and divergent cell-type functions during evolution. In summary, this study not only offers a unique single-cell multi-omics resource for a major crop but also advances our understanding of cell-type functions and the underlying molecular programs in rice.

DOI: 10.1038/s41586-025-09251-0

Source: https://www.nature.com/articles/s41586-025-09251-0