上海大学陈雨团队近日设计了一个多功能纳米酶平台用于协同黑色素瘤治疗：整合酶活性、免疫激活和低温光热效应。2025年6月2日，《德国应用化学》杂志发表了这一成果。

黑色素瘤以快速生长和高侵袭性为特征，导致异常高的恶性程度和显著的转移倾向。目前的治疗方式，如化疗和放疗，由于严重的副作用和免疫抑制作用，疗效有限。因此，制定精确有效的综合治疗策略至关重要。

研究组报告了一种多功能、多酶活性的纳米系统(FeCP@PDA-GOx)，协同整合了饥饿疗法、化学动力学疗法、轻度光热疗法（mPTT）和免疫疗法，以实现多维治疗效果。这种纳米平台利用葡萄糖氧化酶（GOx）、过氧化物酶（POD）、氧化酶（OXD）和过氧化氢酶（CAT）的酶活性来增强肿瘤微环境调节和药物递送效率，最终诱导肿瘤细胞发生铁死亡。 

该系统还建立了一个正反馈回路，以进一步增强其催化性能。此外，它有效地抑制了肿瘤细胞中热休克蛋白的表达，从而增强了mPTT的治疗效果。此外，该系统激活强大的免疫反应，抑制肺转移，并引发全身抗肿瘤作用，以抑制远端肿瘤的生长。实验结果表明，这种多功能纳米平台在黑色素瘤治疗中表现出卓越的疗效和安全性，为个性化医疗和智能治疗策略的发展奠定了坚实的基础。

附：英文论文

Title: Engineering A Multifunctional Nanoenzyme Platform for Synergistic Melanoma Therapy: Integrating Enzyme Activity, Immune Activation, and Low-Temperature Photothermal Effects

Author: Qihang Ding, Haowei Liu, Lishan Yan, Liang Chen, Yu Chen, Jong Seung Kim, Ling Mei

Issue&Volume: 2025-06-02

Abstract: Melanoma is characterized by rapid growth and high invasiveness, resulting in an exceptionally high malignancy and a significant propensity for metastasis. Current therapeutic modalities, such as chemotherapy and radiotherapy, exhibit limited efficacy due to severe side effects and immunosuppressive effects. Consequently, the development of precise and effective integrated therapeutic strategies is of paramount importance. Here, we report a multifunctional and multi-enzyme active nanosystem (FeCP@PDA-GOx) that synergistically integrates starvation therapy, chemodynamic therapy, mild photothermal therapy (mPTT), and immunotherapy to achieve multidimensional therapeutic effects. This nanoplatform harnesses the enzymatic activities of glucose oxidase (GOx), peroxidase (POD), oxidase (OXD), and catalase (CAT) to enhance tumor microenvironment modulation ad drug delivery efficiency, ultimately inducing ferroptosis in tumor cells. The system also establishes a positive feedback loop to further amplify its catalytic performance. Additionally, it effectively suppresses the expression of heat shock proteins in tumor cells, thereby augmenting the therapeutic efficacy of mPTT. Moreover, the system activates robust immune responses, suppressing lung metastasis and eliciting systemic antitumor effects to inhibit the growth of distal tumors. Experimental results demonstrate that this multifunctional nanoplatform exhibits exceptional therapeutic efficacy and safety in melanoma treatment, laying a solid foundation for the advancement of personalized medicine and intelligent therapeutic strategies.

DOI: 10.1002/anie.202505911

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202505911