天津医科大学史学锋研究组近日取得一项新成果。经过不懈努力，他们研究出视觉皮层眼优势可塑性分子机制的研究进展。这一研究成果发表在2025年6月24日出版的国际学术期刊《神经科学通报》上。

视觉皮层是大脑处理视觉信息的重要部分。它表现出结构和功能的可塑性，这对适应复杂的视觉环境至关重要。视觉皮层可塑性的典型表现是关键时期的眼优势可塑性，它涉及许多细胞和分子事件。虽然先前的研究强调视觉皮质神经元及其相关功能分子在视觉可塑性中的作用，但最近的研究发现，细胞外基质和神经胶质等结构因素也参与其中。研究这些分子如何相互作用形成一个复杂的网络，促进视觉皮层的可塑性，对于他们理解视觉系统的发展和弱视等视觉障碍的治疗策略的进步至关重要。

附：英文原文

Title: Recent Advances in the Molecular Mechanisms of Ocular Dominance Plasticity in the Visual Cortex

Author: Qin, Yanglin, Wang, Wei, Gu, Yu, Shi, Xuefeng

Issue&Volume: 2025-06-24

Abstract: The visual cortex is an essential part of the brain for processing visual information. It exhibits structural and functional plasticity, which is crucial for adapting to complex visual environments. The quintessential manifestation of visual cortical plasticity is ocular dominance plasticity during the critical period, which involves numerous cellular and molecular events. While previous studies have emphasized the role of visual cortical neurons and their associated functional molecules in visual plasticity, recent findings have revealed that structural factors such as the extracellular matrix and glia are also involved. Investigating how these molecules interact to form a complex network that facilitates plasticity in the visual cortex is crucial to our understanding of the development of the visual system and the advancement of therapeutic strategies for visual disorders like amblyopia.

DOI: 10.1007/s12264-025-01448-7

Source: https://link.springer.com/article/10.1007/s12264-025-01448-7