上海交通大学医学院李春波小组取得一项新突破。他们提出了精神疾病中的内感受功能障碍和非侵入性神经调节对改善内感受的影响。2025年6月19日，国际知名学术期刊《神经科学通报》发表了这一成果。

最后，研究组指出了重大的研究挑战和未来的发展方向。

据介绍，内感受系统功能障碍被认为是临床症状的重要组成部分，包括焦虑、抑郁、精神病和其他精神障碍。无创神经调节是一种新兴的临床干预手段，近十年来，以调节内感受为目的的无创神经调节研究发展迅速。本文首先概述了内感受信号的通路和评估方法，然后总结了精神疾病的内感受异常和针对内感受的非侵入性神经调节的研究现状，包括干预模式、靶点、内感受措施和潜在的神经生物学机制。

附：英文原文

Title: Interoceptive Dysfunction in Psychiatric Disorders and Non-invasive Neuromodulation for Improving Interoception

Author: Cui, Huiru, Wang, Jijun, Li, Chunbo

Issue&Volume: 2025-06-19

Abstract: Dysfunction of the interoceptive system is recognized as an important component of clinical symptoms, including anxiety, depression, psychosis, and other mental disorders. Non-invasive neuromodulation is an emerging clinical intervention approach, and over the past decade, research on non-invasive neuromodulation aimed at regulating interoception has rapidly developed. This review first outlines the pathways of interoceptive signals and assessment methods, then summarizes the interoceptive abnormalities in psychiatric disorders and current studies for non-invasive neuromodulation targeting interoception, including intervention modes, target sites, interoceptive measures, and potential neurobiological mechanisms. Finally, we discuss significant research challenges and future directions.

DOI: 10.1007/s12264-025-01432-1

Source: https://link.springer.com/article/10.1007/s12264-025-01432-1