西班牙CSIC和巴塞罗那科学技术研究所Daniel Maspoch团队近日实现了从共价有机框架中切除有机大环。这一研究成果于2025年6月19日发表在《科学》杂志上。

分子通常是通过涉及简单分子前体之间化学反应的逐步过程合成的。研究组报告了基于夹断化学方法合成新有机分子的进展，其中分子从有序、扩展的有机结构中切除。 

研究组通过选择性地将它们从共价有机框架中切割出来来合成大环。合成的大环包括8个具有114-、138-和162个原子环的大环聚酰胺，以及一个114个原子环大环聚酰亚胺。这种切除方法将化学有机合成的范围扩展到以前无法接近的大分子。

附：英文原文

Title: Excision of organic macrocycles from covalent organic frameworks

Author: Roberto Sánchez-Naya, Juan Pablo Cavalieri, Jorge Albalad, Alba Cortés-Martínez, Kaiyu Wang, Carles Fuertes-Espinosa, Teodor Parella, Sara Fiori, Esteve Ribas, Aitor Mugarza, Xavi Ribas, Jordi Faraudo, Omar M. Yaghi, Inhar Imaz, Daniel Maspoch

Issue&Volume: 2025-06-19

Abstract: Molecules are typically synthesized through stepwise processes involving chemical reactions between simple molecular precursors. Here, we report an advance in the synthesis of new organic molecules based on the approach of clip-off chemistry, in which molecules are excised from ordered, extended organic structures. We synthesized macrocycles by selectively cleaving them out of covalent organic frameworks. The synthesized macrocycles include eight macrocyclic polyamides with 114-, 138-, and 162-atom rings, and one 114-atom ring macrocyclic polyimide. This excision approach expands the scope of chemical organic synthesis to previously inaccessible macromolecules.

DOI: adw4126

Source: https://www.science.org/doi/10.1126/science.adw4126