Yvonne Ai Lian Lim小组报道了马来半岛原住民集中毛癣菌真菌感染与皮肤微生物组。相关论文于2025年6月17日发表于国际顶尖学术期刊《细胞》杂志上。
研究组通过培养、抗真菌敏感性测试和对OA偏远村庄的集中T.分离株进行测序来调查毛癣的病原学和传播。在区域保守的分离株中，研究组从微生物学和基因组学上发现了耐特比纳芬的集中梭菌。研究人员调查了82种本土OA的皮肤微生物群，发现OA与马来西亚和美国城市人群中独特的微生物群和较低的细菌共生菌（痤疮角质杆菌、表皮葡萄球菌），强调了未被充分研究的人群如何提供前所未有的宿主-微生物群共同进化知识。这些发现为慢性真菌皮肤感染的临床、微生物学和基因组特征提供了有价值的见解，为解决耐药性和有效治疗提供了潜在的信息策略。
研究人员表示，最近暴发的多药耐药真菌感染人体皮肤强调了了解真菌病理生理和传播的重要性。在努力解决各种土著马来西亚半岛人（Orang Asli [OA]）的健康问题时，毛癣（一种集中毛癣真菌皮肤感染）成为一个特别关注的问题。
附：英文原文
Title: Trichophyton concentricum fungal infections and skin microbiomes of Indigenous Peninsular Malaysians
Author: Yi Xian Er, Soo Ching Lee, Chioma Aneke, Sean Conlan, Azdayanti Muslim, Clay Deming, You Che, Nan Jiun Yap, Mian Zi Tee, Nurmanisha Abdull-Majid, Shezryna Shahrizal, Kin Fon Leong, Jungmin Han, Zeyang Shen, Leslie Thian Lung Than, Morgan Park, Izandis Mohd Sayed, Amir Seyedmousavi, Heidi H. Kong, P’ng Loke, Julia A. Segre, Yvonne Ai Lian Lim
Issue&Volume: 2025-06-17
Abstract: Recent outbreaks of multidrug-resistant fungi infecting human skin emphasize the importance of understanding fungal pathophysiology and spread. In efforts to address health concerns with various Indigenous Peninsular Malaysians (Orang Asli [OA]), tinea imbricata—a Trichophyton concentricum fungal skin infection—emerged as a particular concern. We investigated the etiology and transmission of tinea imbricata by culturing, testing antifungal sensitivities, and sequencing T. concentricum isolates in remote OA villages. Among regionally conserved isolates, we identified the emergence of terbinafine-resistant T. concentricum microbiologically and genomically. Investigating the skin microbiomes of 82 Indigenous OA, we found unique microbiota and lower relative abundances of bacterial commensals (Cutibacterium acnes, Staphylococcus epidermidis) among OA versus Malaysian and US urban populations, emphasizing how understudied populations provide unprecedented knowledge on host-microbiome co-evolution. These findings provide valuable insights into clinical, microbiological, and genomic features of chronic fungal skin infections, offering the potential to inform strategies to address drug resistance and effective therapy.
DOI: 10.1016/j.cell.2025.05.034
Source: https://www.cell.com/cell/abstract/S0092-8674(25)00621-X