拮抗作为微生物群落的觅食策略，这一成果由瑞士苏黎世联邦理工学院
课题组发现细菌可以克服这一限制，通过接触依赖性拮抗作用裂解邻近细胞来获取营养。通过单细胞活成像和同位素标记，该研究组发现在饥饿期间，VI型分泌系统（T6SS）裂解邻近细胞，并从裂解细胞中提供营养物质用于生长。拮抗剂的基因组适应性，以减少代谢基因库为特征，以及T6SS在自然环境中细菌分类群中以前未被探索的分布表明，细菌拮抗剂可能有助于许多生态系统中微生物群落的营养转移。
据了解，在自然栖息地，营养物质的供应限制了细菌的生长。
附：英文原文
Title: Antagonism as a foraging strategy in microbial communities
Author: Astrid K. M. Stubbusch, Franois J. Peaudecerf, Kang Soo Lee, Lucas Paoli, Julia Schwartzman, Roman Stocker, Marek Basler, Olga T. Schubert, Martin Ackermann, Cara Magnabosco, Glen G. D’Souza
Issue&Volume: 2025-06-12
Abstract: In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependent antagonism. Using single-cell live imaging and isotopic markers, we found that during starvation, the type VI secretion system (T6SS) lysed neighboring cells and thus provided nutrients from lysing cells for growth. Genomic adaptations in antagonists, characterized by a reduced metabolic gene repertoire, and the previously unexplored distribution of the T6SS across bacterial taxa in natural environments suggest that bacterial antagonism may contribute to nutrient transfer within microbial communities in many ecosystems.
DOI: adr8286
Source: https://www.science.org/doi/10.1126/science.adr8286