近日，上海交通大学姚广保团队实现了基于元DNA边键合的一维开放通道超晶格编程。该项研究成果发表在2025年5月7日出版的《德国应用化学》杂志上。

一维（1D）多孔纳米材料的物理化学性质从根本上受到其通道拓扑特性的影响，包括通道尺寸、形状、排列和连通性。然而，合成涵盖介孔到大孔范围的拓扑多样化的1D多孔晶体仍然是一个重大挑战。研究组提出了一种通过DNA稀疏修饰的间DNA（M-DNA）的边到边组装（边键合）构建1D开放通道超晶格的通用策略。通过编程M-DNA表面稀疏分布的DNA键的刚性和长度，他们实现了具有大孔结构的三角形M-DNA 1D单通道超晶格（3.7±1.2μM）的长程有序组装。 

通过将六角形M-DNA组装成具有介孔结构的1D多通道超晶格（3.6±1.0μM），从而将孔径从140 nm减小到29 nm，孔隙率从94.2%减小到87.5%，进一步证明了这种方法的普遍性。此外，与未组装的三角形M-DNA相比，在三角形M-DNA超晶格上原位生长的超薄金层的电催化活性提高了约3.3倍，这归因于表面积的增加和带隙的加宽。这项工作拓宽了通过DNA纳米技术组装的多孔晶体的设计框架，并突出了它们在催化、能量转换等领域的潜在应用。

附：英文原文

Title: Programming One-Dimensional Open-Channel Superlattices with Edge-Bonding of Meta-DNA

Author: Qin Xu, Le Li, Xiaoliang Chen, Changmao Huang, Jiangbo Liu, Wenhe Ma, Meiyuan Qi, Xiaolei Zuo, Xiaoguo Liu, Mingqiang Li, Xiangyuan Ouyang, Chunhai Fan, Guangbao Yao

Issue&Volume: 2025-05-07

Abstract: The physicochemical properties of one-dimensional (1D) porous nanomaterials are fundamentally influenced by their channel topological characteristics, including channel size, shape, arrangement and connectivity. However, synthesis of topologically diversified 1D porous crystals spanning the mesoporous-to-macroporous range remains a significant challenge. Here, we present a universal strategy for constructing 1D open-channel superlattices through edge-to-edge assembly (edge-bonding) of DNA-sparsely modified meta-DNA (M-DNA). By programming the rigidity and length of sparsely distributed DNA bonds on M-DNA surfaces, we achieved long-range ordered assembly of triangular M-DNA 1D single-channel superlattice (3.7 ± 1.2 μm) with a macroporous structure. The generality of this approach was further demonstrated by assembling hexagonal M-DNA into 1D multi-channel superlattice (3.6 ± 1.0 μm) with a mesoporous structure, thereby reducing the pore size from 140 to 29 nm and the porosity from ~94.2 to ~87.5%. Furthermore, an ultrathin gold layer grown in situ on the triangular M-DNA superlattice exhibited a ~3.3-fold enhancement in electrocatalytic activity compared to non-assembled triangular M-DNA, attributed to the increased surface area and wider bandgap. This work broadens the design framework for porous crystals assembled via DNA nanotechnology and highlights their potential applications in catalysis, energy conversion, and beyond.

DOI: 10.1002/anie.202504223

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202504223